Selection of Criteria in the Diagnosis Approach of Paraneoplastic Fever in Adults With Solid Neoplasia Using a Delphi Method.

IF 1.9 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2025-09-30 DOI:10.1080/07357907.2025.2561037

Matthieu Bainaud, Arnaud Saillant, Nicolas Isambert, Mathieu Puyade, Clément Beuvon

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引用次数: 0

Abstract

Purpose: Paraneoplastic fever (PF) is an exclusion diagnosis that affects around 10% of patients in oncology, combining fever of unknown origin and the presence of cancer. There is no consensus or guidelines in the literature about the minimum criteria required for the diagnosis of (PF). The objective of this survey was to select clinical and paraclinical criteria to establish the diagnosis of PF.

Methods: After a review of the literature, 23 categories and 48 items were set up in an online survey. A two-round Delphi questionnaire survey was carried out from May to August 2021 with the participation of experts in several specialties in France and abroad.

Results: Thirty-seven and 33 experts responded in the first and second rounds respectively. Nine items obtained consensus. Among them, the need to rule out suspected infection by a directed bacteriological statement, an up-to-date imaging and doppler ultrasound of the lower limbs was highly consensual. No biological criteria were retained. Thirty-six propositions did not reach consensus and five were considered useless in this setting.

Conclusion: The 9 selected criteria confirm the importance to eliminating differential fever aetiologies whereas no specific clinical or biological markers were retained. This survey constitute the first consensus of experts in this field.

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用德尔菲法选择成人实体瘤伴副瘤热诊断标准。

目的：副肿瘤热（PF）是一种排除性诊断，影响约10%的肿瘤患者，结合不明原因的发热和癌症的存在。关于（PF）诊断所需的最低标准，文献中没有共识或指南。本调查的目的是选择临床和临床旁的标准来建立对前列腺癌的诊断。方法：在查阅文献的基础上，建立了23个类别和48个项目的在线调查。2021年5月至8月，在法国和国外多个专业专家的参与下，进行了两轮德尔菲问卷调查。结果：第一轮和第二轮分别有37名和33名专家回答。9项议题达成共识。其中，需要排除疑似感染的指导细菌学声明，最新的成像和多普勒超声下肢是高度一致的。没有保留生物学标准。36项提案没有达成协商一致意见，其中5项被认为是无用的。结论：所选的9项诊断标准在未保留特异性临床或生物学标志物的情况下，证实了排除发热病因的重要性。这项调查构成了这一领域专家的第一个共识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.