Brain structural alterations correlate with motor dysfunction in children with spastic cerebral palsy: a quantitative MRI study.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-29 DOI:10.1186/s40001-025-03194-y

Qiang Wang, Jiale Zhang, Xiang Ren, Qijia Zhan, Wenbin Jiang

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引用次数: 0

Abstract

Background: Spastic cerebral palsy (CP) is a common cause of motor disability in children which caused by non-progressive brain injury. This study aimed to investigate the correlation between quantitative brain MRI parameters and motor dysfunction in children with spastic CP.

Methods: 91 children with spastic CP and 91 controls were recruited. Brain volumes were measured using high-resolution T1-weighted Magnetic resonance imaging (MRI). Gross motor function was assessed using Gross Motor Function Measure-66 score (GMFM-66) and the muscle tone was evaluated by modified Ashworth scale and scored by modified Ashworth scale score.

Results: Children with spastic CP showed significantly reduced total brain volume, white matter volume, gray matter volume, and white matter/total brain volume ratio compared to controls. In children with spastic CP, white matter volume and white matter/total brain volume ratio positively correlated with GMFM-66 scores (r = 0.56, p < 0.001; r = 0.47, p < 0.001). The muscle tone of specific muscles negatively correlated with brain volumes.

Conclusions: White matter volumes are closely related to motor dysfunction in children with spastic CP. Quantitative MRI may serve as objective biomarkers for evaluating the severity and prognosis of spastic CP, providing basis for individualized rehabilitation strategies.

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痉挛性脑瘫患儿脑结构改变与运动功能障碍相关：一项定量MRI研究。

背景：痉挛性脑瘫（CP）是由非进行性脑损伤引起的儿童运动障碍的常见原因。本研究旨在探讨痉挛性脑瘫患儿脑MRI定量参数与运动功能障碍的相关性。方法：选取91例痉挛性脑瘫患儿和91例对照组。采用高分辨率t1加权磁共振成像（MRI）测量脑容量。采用大运动功能量表（GMFM-66）评定大运动功能，采用改良Ashworth量表评定肌张力，并按改良Ashworth量表评分。结果：与对照组相比，痉挛性脑瘫患儿的总脑容量、白质体积、灰质体积和白质/总脑体积比显著降低。结论：脑白质体积与痉挛性脑瘫患儿运动功能障碍密切相关，定量MRI可作为评价痉挛性脑瘫严重程度及预后的客观生物标志物，为制定个性化康复策略提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.