Temporal and geographic trends in extended-spectrum cephalosporins resistance among Neisseria gonorrhoeae isolates worldwide: a systematic review and meta-analysis.

IF 3 3区医学 Q2 INFECTIOUS DISEASES

BMC Infectious Diseases Pub Date : 2025-09-29 DOI:10.1186/s12879-025-11601-2

Laith B Alhusseini, Bita Hasani, Firas Nabeeh Jaafar, Masoumeh Beig, Sara Abbasian, Khalil Azizian

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引用次数: 0

Abstract

The global emergence of antibiotic resistance in Neisseria gonorrhoeae (NG) infections poses a critical public health challenge. This study aimed to evaluate global resistance rates to extended-spectrum cephalosporins (ESCs) in N. gonorrhoeae, considering factors such as time, geography, antimicrobial susceptibility testing (AST), and resistance interpretation. A systematic review and meta-analysis (from 1988 to 2025) of 252 studies from 71 countries reported a weighted pooled resistance rate (WPR) of ≤ 2.5% for ESCs. Significant temporal variation in ESCs-resistant isolates (P < 0.05) underscores the dynamic nature of resistance development. Significantly, there was a difference in penicillin resistance rates between countries/ continents, and AST (P < 0.001). These findings emphasize the urgent need for effective antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems to combat antimicrobial resistance in gonococcal infections.

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淋病奈瑟菌世界范围内广谱头孢菌素耐药的时间和地理趋势：一项系统回顾和荟萃分析。

全球淋病奈瑟菌（NG）感染抗生素耐药性的出现对公共卫生构成了重大挑战。本研究旨在评估淋病奈瑟菌对广谱头孢菌素（ESCs）的全球耐药率，考虑时间、地理、抗菌药物敏感性试验（AST）和耐药性解释等因素。对来自71个国家的252项研究的系统回顾和荟萃分析（1988年至2025年）报告，ESCs的加权综合耐药率(WPR)≤2.5%。escs耐药菌株的时间差异显著(P

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来源期刊

BMC Infectious Diseases 医学-传染病学

CiteScore

6.50

自引率

0.00%

发文量

860

审稿时长

3.3 months

期刊介绍： BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.