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Serum Vitamin D Levels Were Not Associated With the Risk of Aneurysmal Subarachnoid Hemorrhage: A Large Cohort Study With Propensity Score Matching and Mendelian Randomization Analysis

IF 5 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-09-30 DOI:10.1111/cns.70617

Haoran Qiu, Kai Chen, Yang Yu, Ziyin Song, Jingzheng Liu, Lvyin Luo, Xinlong Ma, Zhaoyang Yuan, Maogui Li, Jianfeng Zhuang, Mingxiang Zhang, Wandong Su, Yunyan Wang, Donghai Wang, Weiying Zhong

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引用次数: 0

Abstract

Background

Vitamin D (VitD) may protect arterial health, but its link to cerebral aneurysm rupture remains unclear. This study aims to investigate the correlation between serum VitD levels and the risk of aneurysmal subarachnoid hemorrhage (aSAH).

Methods

This retrospective study included patients with ruptured or unruptured aneurysms treated between 2018 and 2021. Univariate and multivariate analyses were conducted. Propensity score matching (PSM) analysis was conducted to balance confounding factors. Furthermore, the causal relationship between VitD and aSAH was investigated using a two-sample Mendelian randomization (MR) analysis. Summary-level data for the exposure (VitD) and outcome (aSAH) were obtained from public genome-wide association study datasets. Multiple MR methods, including inverse variance weighted, MR-Egger, weighted median, simple mode, and weighted mode, were utilized to assess causality. Sensitivity analyses were conducted to evaluate the robustness and reliability of the causal estimates.

Results

A total of 499 patients with 619 intracranial aneurysms were included. Among them, 337 (68%) were female, 184 cases (36.9%) had ruptured aneurysms, and 105 (21.0%) had multiple aneurysms. VitD levels and VitD deficiency showed no association with aSAH in univariate or multivariate analysis before PSM (p > 0.05). After PSM (112 matched aSAH patients), VitD levels and VitD deficiency remained unassociated with the risk of aSAH (p = 0.947). MR analysis, including inverse variance weighted methods, found no causal link between VitD levels and aSAH (OR: 1.00; 95% CI: 0.82–1.23; p = 0.966).

Conclusion

This study found that serum VitD levels are neither associated with nor causally linked to aSAH. The inverse associations observed in previous studies may be attributed to confounding factors or reverse causation. A prospective, large-scale study with long-term follow-up is warranted to validate these findings.

Abstract Image

查看原文本刊更多论文

血清维生素D水平与动脉瘤性蛛网膜下腔出血的风险无关：一项倾向评分匹配和孟德尔随机化分析的大型队列研究

背景：维生素D （VitD）可能保护动脉健康，但其与脑动脉瘤破裂的关系尚不清楚。本研究旨在探讨血清VitD水平与动脉瘤性蛛网膜下腔出血（aSAH）风险的相关性。方法：本回顾性研究纳入了2018年至2021年间治疗的破裂或未破裂动脉瘤患者。进行单因素和多因素分析。采用倾向得分匹配（PSM）分析平衡混杂因素。此外，使用双样本孟德尔随机化（MR）分析调查了VitD和aSAH之间的因果关系。暴露（VitD）和结果（aSAH）的概要数据来自公开的全基因组关联研究数据集。多重MR方法，包括反方差加权、MR- egger、加权中位数、简单模式和加权模式，用于评估因果关系。进行敏感性分析以评估因果估计的稳健性和可靠性。结果：共纳入499例颅内动脉瘤619例。其中女性337例（68%），动脉瘤破裂184例（36.9%），多发动脉瘤105例（21.0%）。单因素分析和多因素分析显示，PSM前维生素d水平和维生素d缺乏与aSAH无相关性（p < 0.05）。在PSM（112例匹配的aSAH患者）后，VitD水平和VitD缺乏与aSAH的风险无关（p = 0.947）。磁共振分析，包括反方差加权方法，发现VitD水平与aSAH之间没有因果关系（OR: 1.00; 95% CI: 0.82-1.23; p = 0.966）。结论：本研究发现血清维生素d水平与aSAH无关，也与aSAH无因果关系。在以往的研究中观察到的负相关可能归因于混杂因素或反向因果关系。有必要进行一项前瞻性、大规模的长期随访研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.

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