Longitudinal changes in cognitive function and its related factors in older type 1 diabetes mellitus patients without dementia.

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-30 DOI:10.1111/jdi.70168

Kaoru Nagasawa, Kimio Matsumura, Takayasu Uchida, Yuya Suzuki, Akihiro Nishimura, Yukifusa Igeta, Takashi Sakurai, Yasumichi Mori

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Abstract

Aims: This study aimed to assess the longitudinal changes in cognitive function and associated factors in older patients with type 1 diabetes mellitus without dementia.

Materials and methods: Older patients above 65 years of age with type 1 diabetes mellitus and without dementia were included in this study. They were assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment, Japanese version, at baseline and 3 years after. Cognitive decline was defined as a reduction of two or more points in the total Montreal Cognitive Assessment score over 3 years. Baseline diabetes-related factors were compared between the cognitive decrement and non-decrement groups to identify risk factors associated with cognitive impairment.

Results: Twenty-eight patients aged 71.5 ± 4.0 years were included. Total scores for the Mini-Mental State Examination and the Montreal Cognitive Assessment (Japanese version) at baseline and after 3 years of follow-up showed no significant changes (P = 0.38, P = 0.26). Delayed recall sub-scores of both tests were significantly lower after 3 years compared to their corresponding levels at baseline (P = 0.007, P = 0.04); 32% experienced impaired cognition after 3 years compared to baseline examination. Decline in total Montreal Cognitive Assessment score was significantly associated with the onset age (β = 0.54, P = 0.026) and duration of type-1 diabetes mellitus (β = -4.77, P = 0.026).

Conclusions: Patients with type-1 diabetes mellitus without dementia experience a progressive decline in memory over time. Long durations of type-1 diabetes mellitus are associated with cognitive decline even without dementia.

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老年1型糖尿病无痴呆患者认知功能的纵向变化及其相关因素

目的：本研究旨在评估老年1型糖尿病合并痴呆患者认知功能的纵向变化及其相关因素。材料与方法：本研究纳入年龄大于65岁的老年1型糖尿病患者，且无痴呆。在基线和3年后，使用简易精神状态检查和蒙特利尔认知评估（日语版）对他们进行评估。认知能力下降被定义为蒙特利尔认知能力评估总分在3年内下降2分或更多。比较认知功能减退组和非认知功能减退组的基线糖尿病相关因素，以确定与认知功能减退相关的危险因素。结果：纳入28例患者，年龄71.5±4.0岁。迷你精神状态检查和蒙特利尔认知评估（日语版）总分在基线和随访3年后无显著变化（P = 0.38, P = 0.26）。3年后，两项测试的延迟回忆分值均显著低于基线时的相应水平（P = 0.007, P = 0.04）；与基线检查相比，32%的人在3年后出现认知障碍。蒙特利尔认知评估总分下降与发病年龄（β = 0.54, P = 0.026）和1型糖尿病病程（β = -4.77, P = 0.026）显著相关。结论：无痴呆的1型糖尿病患者随着时间的推移记忆力逐渐下降。即使没有痴呆，长期的1型糖尿病也与认知能力下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).