Synthesis and Cytotoxicity of New 1,2,3-Triazole Derivatives of Abietic Acid

Abstract

A series of abietic acid derivatives modified with a triazole moiety at the C-18 position were synthesized using Huisgen 1,3-dipolar cycloaddition reaction of 18-azidoabietane with alkynes. The antitumor activity of the synthesized compounds was investigated through human cervical cancer cells (HeLa), human breast cancer cells (MCF-7) and human renal epithelial cells (HEK-293T). The outcome indicated that compounds 5e, 5f, 5j exhibited positive inhibitory activity against the tested tumor cell lines. In particular, the IC₅₀ value for the inhibitory activity of compound 5e against human breast cancer cells (MCF-7) was 11.2 μmol/L.