Synthesis of N-Arylsulfonyl Anabasines

Abstract

Reactions of the alkaloid anabasine with benzene-, p-toluene-, o-methoxyphenyl-, 3,4-dimethylbenzene-, 2,4,6-trimethylbenzene-, and m-nitrophenylsulfonyl chlorides under relatively mild conditions afforded the corresponding N-arylsulfonyl anabasines in good yields. Results of in vitro antimicrobial tests showed that the compounds did not exhibit antibacterial effects against microorganism strains.