Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery.

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2025-09-30 DOI:10.1002/mds.70042

Martijn G J de Neeling,Stijn Geraats,Bart E K S Swinnen,Mariëlle J Stam,Rob M A de Bie,Bernadette C M van Wijk,P Rick Schuurman,Arthur W G Buijink,Martijn Beudel

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Abstract

BACKGROUND Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for patients with advanced Parkinson's disease (PD). Early programming of DBS may be complicated by the postoperative "stun effect," which also may impact local field potentials (LFPs). METHODS Percept PC neurostimulators (Medtronic) were used to continuously record LFPs from the STN in 32 PD patients at home during the first 2 months after DBS surgery. Average beta peak power ("beta power") per day was analyzed using change-point analysis. RESULTS Median beta power across patients showed an upward trend with a changepoint 24 to 40 days after surgery. Median beta power directly following DBS activation did not significantly drop but continued to increase beyond the DBS activation visit. CONCLUSION The neurophysiological stun effect persists for at least 3 weeks and should be taken into consideration when timing and applying sensing-informed or adaptive DBS based on beta power. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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脑深部电刺激手术后帕金森病患者的眩晕效应与β功率的时间动态。

背景丘脑底核深部脑刺激（DBS）是治疗晚期帕金森病（PD）的有效方法。术后“昏迷效应”可能会影响局部场电位（lfp），从而使DBS的早期程序变得复杂。方法使用spercept PC神经刺激器（Medtronic）连续记录32例PD患者DBS术后2个月的STN lfp。使用变化点分析分析每天平均峰值功率（“beta功率”）。结果患者的中位β功率在术后24 ~ 40天呈上升趋势。激活DBS后的中位β功率没有显著下降，但在激活DBS后继续增加。结论神经生理性昏迷效应至少持续3周，在选择时机和应用感应感应或基于β功率的自适应DBS时应予以考虑。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.