Predictive value of 8-hydroxy-2'-deoxyguanosine and 8-nitroguanine production in radiation-induced skin damage after postoperative breast cancer radiotherapy.

Q3 Medicine
Exploration of targeted anti-tumor therapy Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI:10.37349/etat.2025.1002336
Emmanouil K Verigos, Sofia Sagredou, Kosmas E Verigos, Kyriakos Orfanakos, Constantinos E Alifieris, Maria V Deligiorgi, Panagiotis Dalezis, Mihalis I Panayiotidis, Petros N Karamanakos, Dimitrios T Trafalis
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引用次数: 0

Abstract

Aim: During radiation treatment, reactive oxygen species (ROS) and nitrogen species (RNS) are produced and, by extension, DNA adducts known as 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NG), respectively. However, one of the most common side effects induced by radiotherapy is skin toxicity, which affects patients' quality of life. In the present study, we aimed to investigate the potential predictive value of 8-OHdG and 8-NG by exploring the correlations between the alterations in the concentration levels of the two lesions and radiation-induced tissue injury upon exposure to external beam radiotherapy.

Methods: For the purpose of this work, we collected blood serum samples from 33 breast cancer patients who received adjuvant radiotherapy. To conduct statistical analysis, we used: (1) linear adjustment to correlate the percent changes of 8-OHdG and 8-NG with the degree of toxicity; and (2) polynomial adaptation and exponential fitting to correlate the percent changes of 8-OHdG and 8-NG with the correlation coefficient r for the development of radiation dermatitis, respectively.

Results: According to our findings, there is a statistically significant correlation between the alterations in the 8-OHdG and 8-NG levels and skin grade toxicity across time and varying radiation doses (p < 0.05).

Conclusions: Both DNA lesions seem to possess a promising predictive role in radiation dermatitis, while the severity and exact grade of radiation-induced skin toxicity can be determined.

Abstract Image

Abstract Image

Abstract Image

8-羟基-2'-脱氧鸟嘌呤和8-硝基鸟嘌呤的产生对乳腺癌术后放疗后放射性皮肤损伤的预测价值。
目的:在放射治疗过程中,产生活性氧(ROS)和氮(RNS),进而产生DNA加合物8-羟基-2'-脱氧鸟苷(8-OHdG)和8-硝基鸟嘌呤(8-NG)。然而,放射治疗最常见的副作用之一是皮肤毒性,影响患者的生活质量。在本研究中,我们旨在探讨8-OHdG和8-NG的潜在预测价值,通过探索两种病变的浓度水平变化与放射治疗后辐射诱导的组织损伤之间的相关性。方法:为开展这项工作,我们采集了33例接受辅助放疗的乳腺癌患者的血清样本。为了进行统计分析,我们采用了:(1)线性调整8-OHdG和8-NG的百分比变化与毒性程度的相关性;(2)多项式自适应和指数拟合,分别将8-OHdG和8-NG的变化百分比与放射性皮炎发生的相关系数r关联起来。结果:根据我们的研究结果,8-OHdG和8-NG水平的变化与皮肤级毒性随时间和不同辐射剂量的相关性有统计学意义(p < 0.05)。结论:这两种DNA损伤似乎在放射性皮炎中具有很好的预测作用,而辐射引起的皮肤毒性的严重程度和确切等级可以确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.80
自引率
0.00%
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审稿时长
13 weeks
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