Echocardiographic Markers of Prognosis in Patients Undergoing Ventricular Arrhythmia Ablation

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2025-09-29 DOI:10.1111/echo.70307

Lisa Steen Duus, Maria Dons, Morten Lock Hansen, Rene Worck, Martin H. Ruwald, Arne Johannessen, Jim Hansen, Tor Biering-Sørensen

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引用次数: 0

Abstract

Background

Radiofrequency catheter ablation (RFA) plays an increasing role in the treatment of ventricular arrhythmias (VAs). This study aimed to evaluate the echocardiographic and clinical characteristics of patients undergoing first-time RFA for VAs and to identify risk factors associated with VA recurrence, implantable cardioverter-defibrillator (ICD) therapy, and mortality.

Methods

We studied patients scheduled for first-time RFA for VAs from 2011 to 2022 with available transthoracic echocardiography before the procedure. The primary outcome was defined as VA recurrence, and the secondary outcome was defined as appropriate ICD therapy and mortality. Uni- and multivariable Cox hazards regression models were used to assess the prognostic value of cardiac structure and function by echocardiography.

Results

A total of 218 patients (mean age 61 years [±15], 62% men, mean LVEF 51% [IQR: 44; 57]) underwent RFA during the study period. Of these, 90 patients (41%) had VA recurrence while 52 patients (24%) developed the secondary outcome during a median follow-up time of 3.1 years (IQR: 1.1; 6.7 years). Patients with ventricular tachycardia had significantly more right—and left ventricular (LV) dysfunction, compared to patients with premature ventricular contractions. No echocardiographic measures were associated with VA recurrence, while several echocardiographic measures were associated with the secondary outcome. LV mass index, LV ejection fraction, global longitudinal strain, and VA recurrence showed the highest predictive values of the secondary outcome.

Conclusion

In patients undergoing RFA for VAs, several echocardiographic measures may identify patients at risk of an adverse outcome.

Abstract Image

查看原文本刊更多论文

室性心律失常消融患者预后的超声心动图指标。

背景：射频导管消融（RFA）在室性心律失常（VAs）的治疗中发挥着越来越重要的作用。本研究旨在评估首次行体外循环消融术患者的超声心动图和临床特征，并确定与体外循环复发、植入式心律转复除颤器（ICD）治疗和死亡率相关的危险因素。方法：我们研究了2011年至2022年期间计划首次为VAs进行RFA的患者，术前有可用的经胸超声心动图。主要终点定义为VA复发，次要终点定义为适当的ICD治疗和死亡率。采用单变量和多变量Cox风险回归模型评估超声心动图对心脏结构和功能的预后价值。结果：研究期间共有218例患者（平均年龄61岁[±15]，男性62%，平均LVEF 51% [IQR: 44； 57]）接受了RFA治疗。其中，90名患者（41%）出现VA复发，52名患者（24%）在中位随访3.1年（IQR: 1.1； 6.7年）期间出现继发性预后。与室性早搏患者相比，室性心动过速患者有更多的左、右心室功能障碍。没有超声心动图测量与VA复发相关，而一些超声心动图测量与次要结果相关。左室质量指数、左室射血分数、整体纵向应变和VA复发对次要预后的预测价值最高。结论：在为VAs接受RFA的患者中，一些超声心动图测量可以识别出有不良结果风险的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.