Exploring the Frontiers of Diabetes Vaccination.

Abstract

Diabetes is undeniably one of the most prevalent global health problems with a high risk burden. The present forms of management, insulin administration and lifestyle changes, may address the origins and consequences of the disease to some extent, but the answers are still far from being complete. This phenomenon is bringing in a rising number of people who seek for new therapies and immunization. Through the years, vaccine usage for prevention of infectious diseases has been researched for its potential use in the delay, prevention, or reversal of diabetes. These vaccines, which aim at different processes, including autoimmunity, inflammation, and insulin resistance, play a role in both Type 1 and Type 2 diabetes. Among the candidates for vaccine types are the IA-2 peptide vaccines, glucose-regulating vaccines, incretin-based vaccines, and protein-based vaccines. In this review, we offer a snapshot of the current efforts in diabetes vaccine development, describing the target molecules on the antigens, their mechanisms of action, and the research progress status. It highlights the imperativeness of importance of ongoing investigations for the invention of vaccines as well as the provision of new therapeutic options for diabetic persons.