Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in subsequent frozen embryo transfers?

IF 1.4 4区 生物学 Q4 CELL BIOLOGY
Zygote Pub Date : 2025-09-29 DOI:10.1017/S0967199425100154
Inbal Navon, Hadas Ganer, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H Dahan
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引用次数: 0

Abstract

Aim: High oestradiol levels during in vitro fertilization (IVF) fresh cycles have been linked to adverse obstetric outcomes, yet whether this is due to endometrial or oocyte effects remains unclear. Investigating subsequent frozen embryo transfer (FET) cycles can help clarify the origins of these effects. This study aimed to evaluate obstetric outcomes and placental histology in FET cycles for patients with elevated serum oestradiol levels during the ovarian stimulation cycle in which the embryos were created.

Methods: A single centre retrospective cohort study of live singleton deliveries after IVF with programmed FET from 2009 to 2017. High oestradiol during ovarian stimulation was defined as ≥10,000 pmol/L. We compared obstetric outcomes and placental findings between pregnancies with high oestradiol levels in the preceding ovarian stimulation cycle and a control group.

Results: We analyzed 114 deliveries in the high oestradiol group and 194 in the control group. Baseline demographics were comparable between groups. No significant differences were observed in obstetric outcomes, including low birth weight, preeclampsia and preterm delivery. The placental macroscopic and histopathological findings did not significantly differ between the groups as well.

Conclusion: High oestradiol during the ovarian stimulation cycle used to create embryos is not associated with adverse obstetric outcomes or placental pathologies in pregnancies following FET. This is consistent with an endometrial effect of high oestradiol and thus support the practice of a freeze all approach in high oestradiol cycles.

刺激期间高血清雌二醇是否会影响随后冷冻胚胎移植的产科结局和胎盘病理?
目的:体外受精(IVF)新鲜周期中的高雌二醇水平与不良产科结局有关,但这是由于子宫内膜还是卵母细胞的影响尚不清楚。研究随后的冷冻胚胎移植(FET)周期可以帮助阐明这些影响的起源。本研究旨在评估在胚胎产生的卵巢刺激周期中血清雌二醇水平升高的患者在FET周期中的产科结局和胎盘组织学。方法:对2009年至2017年体外受精后单胎活产的单中心回顾性队列研究。卵巢刺激时高雌二醇定义为≥10,000 pmol/L。我们比较了在卵巢刺激周期前雌二醇水平高的孕妇和对照组的产科结局和胎盘结果。结果:我们分析了高雌二醇组114例分娩和对照组194例分娩。各组之间的基线人口统计数据具有可比性。在分娩结局方面,包括低出生体重、先兆子痫和早产,没有观察到显著差异。两组间胎盘的宏观和组织病理学检查结果也无显著差异。结论:在卵巢刺激周期中用于制造胚胎的高雌二醇与FET后妊娠的不良产科结局或胎盘病理无关。这与高雌二醇对子宫内膜的影响是一致的,因此支持在高雌二醇周期中冻结所有方法的实践。
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来源期刊
Zygote
Zygote 生物-发育生物学
CiteScore
1.70
自引率
5.90%
发文量
117
审稿时长
6-12 weeks
期刊介绍: An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies on gametogenesis through fertilization to gastrulation in animals and humans. The scope has been expanded to include clinical papers, molecular and developmental genetics. The editors will favour work describing fundamental processes in the cellular and molecular mechanisms of animal development, and, in particular, the identification of unifying principles in biology. Nonetheless, new technologies, review articles, debates and letters will become a prominent feature.
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