Neonatal ischemic stroke potentially associated with transplacental passage of maternal anti-cardiolipin immunoglobulin G antibodies: A case report.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-09-29 DOI:10.1177/09612033251386089
Hiroshi Oiwa, Hideyuki Hawaka, Yuichiro Fujieda, Naoko Ueno, Seishi Sumi
{"title":"Neonatal ischemic stroke potentially associated with transplacental passage of maternal anti-cardiolipin immunoglobulin G antibodies: A case report.","authors":"Hiroshi Oiwa, Hideyuki Hawaka, Yuichiro Fujieda, Naoko Ueno, Seishi Sumi","doi":"10.1177/09612033251386089","DOIUrl":null,"url":null,"abstract":"<p><p>A baby girl, born to a 35-year-old mother, was admitted at 14.5 hours of life due to apnoea and seizures. Diffusion-weighted magnetic resonance imaging revealed multiple ischemic lesions. Laboratory screening for thrombophilia showed elevated levels of anti-cardiolipin IgG antibodies (aCL-IgG). The mother also tested positive for aCL-IgG, raising the possibility of transplacental antibody transfer. The neonate's aCL-IgG levels gradually declined and normalized by 4 months of age. Although causality cannot be established, this case suggests a potential association between transient maternal antiphospholipid antibodies and neonatal ischemic stroke.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033251386089"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251386089","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

A baby girl, born to a 35-year-old mother, was admitted at 14.5 hours of life due to apnoea and seizures. Diffusion-weighted magnetic resonance imaging revealed multiple ischemic lesions. Laboratory screening for thrombophilia showed elevated levels of anti-cardiolipin IgG antibodies (aCL-IgG). The mother also tested positive for aCL-IgG, raising the possibility of transplacental antibody transfer. The neonate's aCL-IgG levels gradually declined and normalized by 4 months of age. Although causality cannot be established, this case suggests a potential association between transient maternal antiphospholipid antibodies and neonatal ischemic stroke.

新生儿缺血性中风可能与母体抗心磷脂免疫球蛋白G抗体经胎盘传递相关:1例报告。
一位35岁的母亲生下了一名女婴,由于呼吸暂停和癫痫发作,在出生14.5小时后入院。磁共振弥散加权成像显示多发缺血性病变。血栓病的实验室筛查显示抗心磷脂IgG抗体(aCL-IgG)水平升高。母亲的aCL-IgG检测也呈阳性,这增加了经胎盘抗体转移的可能性。新生儿的aCL-IgG水平在4月龄时逐渐下降并恢复正常。虽然不能确定因果关系,但本病例提示母体短暂性抗磷脂抗体与新生儿缺血性中风之间存在潜在关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信