Peritoneal Metastases in Gastrointestinal Malignancies: A Review of the Pathophysiology of Metastasis and the Tumour Microenvironment.

IF 1.9 3区 医学 Q3 ONCOLOGY
Milee Patel, Kristen Limbach, Elizabeth Martin, Matthew Burow, Kevin M Sullivan
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引用次数: 0

Abstract

Peritoneal metastasis is a significant source of morbidity and mortality for patients with cancer from gastrointestinal origin such as gastric, colorectal, and appendiceal cancers, and treatment options are limited. Cross-sectional imaging is limited in sensitivity and specificity, and treating peritoneal metastases is limited by the bioavailability of systemic cytotoxic chemotherapy and metastatic burden. Within this review, we specifically explore the pathophysiology underlying peritoneal metastasis while emphasising the contributions of the tumour microenvironment and immune system.

胃肠道恶性肿瘤腹膜转移:转移的病理生理和肿瘤微环境的综述。
腹膜转移是胃肠道癌症(如胃癌、结直肠癌和阑尾癌)患者发病率和死亡率的重要来源,治疗选择有限。横断成像在敏感性和特异性上是有限的,治疗腹膜转移受到全身细胞毒性化疗的生物利用度和转移负担的限制。在这篇综述中,我们特别探讨了腹膜转移的病理生理机制,同时强调了肿瘤微环境和免疫系统的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.70
自引率
4.00%
发文量
367
审稿时长
2 months
期刊介绍: The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.
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