2025 Focused Update of the Seoul Consensus on Gastroesophageal Reflux Disease: Evidence-based Recommendations on Acid Suppressive Therapy.

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY
Cheal Wung Huh, Jin Won Chang, Nak-Hoon Son, Da Hyun Jung, Hye-Kyung Jung, Seung Joo Kang, Seung Young Kim, Miyoung Choi, Da Mi Jeong, Hyun Jin Kim, Moo In Park, In-Kyung Sung, Young Hoon Youn, Kwang Jae Lee
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引用次数: 0

Abstract

Gastroesophageal reflux disease (GERD) is a chronic and relapsing gastrointestinal disorder characterized by the reflux of gastric contents into the esophagus, leading to troublesome symptoms and/or complications. Since the publication of the 2020 Seoul Consensus on GERD, significant new evidence has emerged, particularly regarding acid-suppressive therapies and diagnostic approaches. This 2025 focused update aims to refine GERD management strategies by incorporating the latest evidence on acid suppressive therapies and regional considerations in Asian populations. This study builds on the 2020 Seoul Consensus by integrating systematic reviews, meta-analyses, and expert consensuses to offer updated recommendations for the definition and medical treatment of GERD. These guidelines incorporate recent advances in acidsuppressive therapies, particularly potassium-competitive acid blockers, and adopt updated diagnostic frameworks in accordance with the Lyon Consensus 2.0. Key clinical questions were identified and structured using the following format: population, intervention, comparator, and outcome. The resulting recommendations address the initial treatment, long-term maintenance strategies, and role of personalized therapy based on disease severity, such as the grade of reflux esophagitis. Six key statements are presented: updated definition and classification of GERD (Statement 1); initial and long-term treatment strategies tailored to GERD phenotypes, such as non-erosive reflux disease, mild erosive esophagitis, and severe erosive esophagitis (Statements 2-5); and dose optimization strategies for long-term safety (Statement 6). These guidelines aim to support gastroenterologists and general healthcare providers in making individualized evidence-based decisions for GERD management.

2025年胃食管反流病首尔共识的重点更新:抑酸治疗的循证建议
胃食管反流病(GERD)是一种慢性和复发性胃肠道疾病,其特征是胃内容物反流到食道,导致麻烦的症状和/或并发症。自2020年关于GERD的首尔共识发表以来,出现了重要的新证据,特别是关于抑酸疗法和诊断方法。这一2025年的重点更新旨在通过纳入酸抑制疗法的最新证据和亚洲人群的区域考虑来完善GERD管理策略。本研究建立在2020年首尔共识的基础上,通过整合系统评价、荟萃分析和专家共识,为胃食管反流病的定义和医学治疗提供最新建议。这些指南纳入了抑酸疗法的最新进展,特别是钾竞争性酸阻滞剂,并采用了根据里昂共识2.0更新的诊断框架。使用以下格式确定和组织关键临床问题:人群、干预措施、比较物和结果。由此产生的建议涉及初始治疗、长期维持策略以及基于疾病严重程度(如反流性食管炎的等级)的个性化治疗的作用。提出了六个关键陈述:更新了GERD的定义和分类(陈述1);针对GERD表型量身定制的初始和长期治疗策略,如非糜烂性反流疾病、轻度糜烂性食管炎和严重糜烂性食管炎(陈述2-5);以及长期安全性的剂量优化策略(表述6)。这些指南旨在支持胃肠病学家和一般医疗保健提供者为胃食管反流管理做出个性化的循证决策。
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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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