Evaluation of Serum Ischemia-Modified Albumin And Oxidative Stress Markers in Patients with Sepsis.

Abstract

Purpose: The most common causes of mortality and morbidity in patients followed up in intensive care are bacterial infections and sepsis. Rapid and timely intervention is essential for the successful treatment of sepsis. Therefore, this study aimed to reveal the relationships between mortality and patients by examining ıschemia-modified albumin, APACHE II, CRP, PCT, lactate, WBC, NLR, PLR, SII, platelet, and lactate/IMA (LIMA) values in patients with sepsis followed up in intensive care units.

Material method: The study was planned as prospective and single-center. 31 patients diagnosed with sepsis were included in the study. The first 24 hours and 5th day values of patients diagnosed with sepsis were examined and recorded. The biomarkers and APACHE-II score of patients diagnosed with sepsis were examined for predictive power of 28-day mortality.

Results: Thirty-one patients diagnosed with sepsis from the Anesthesia Intensive Care Unit were included in the study. Of the total patients, 21 (67.7%) were male and 10 (32.3%) were female. The APACHE-II score of patients diagnosed with sepsis in the first 24 hours (AUC:0.891, 95% CI: 77.6-100, p<0.0001) was determined to be the best indicator for predicting 28-day mortality. In addition, neutrophil/lymphocyte ratio on day 5 (AUC:0.765, 95% CI:59.3-93.7, p:0.013), Lactate/IMA on day 1 (AUC:0.628, 95% CI:59.3-83.9, p:0.230) and SII on day 5 (AUC:0.624, 95% CI:42.3-82.5, p:0.246) were also determined as other biomarkers that can be used to predict 28-day mortality.

Conclusion: APACHE-II score still maintains its place in predicting mortality in patients with sepsis. No biomarker alone has been able to surpass this score, and markers obtained in combination such as NLR, LIMA and SII may be helpful in predicting mortality. New and large-scale studies are needed on this subject.