{"title":"Comparison of Efficacy in the Treatment of Otomycosis using 10% Povidone-Iodine and Clotrimazole Solution: Randomized, Double-Blind Control Trial.","authors":"Pilasluck Numchaichanakij, Pattraporn Kreesaeng","doi":"10.1055/s-0045-1810001","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The main treatment of otomycosis has required the use of topical antifungal drops and/or acidifying agents. However, because of the availability issues of antifungal drops in developing countries, treatment with acidifying agents alone is necessary.</p><p><strong>Objective: </strong>The objective of this study was to compare the efficacy in the treatment of otomycosis using a 10% povidone-iodine and clotrimazole solution.</p><p><strong>Methods: </strong>Patients with otomycosis were assigned to 10% povidone-iodine group and Clotrimazole group. The patients were evaluated on the response of each group at 1, 2,4 and 8 weeks.</p><p><strong>Results: </strong>93 patients were assigned to the 10% povidone-iodine group and 95 patients to the Clotrimazole group. the response to treatment between groups. In the second week after treatment, 37.64% of the 10% povidone-iodine group and 40% of the Clotrimazole group had a good response to treatment (p = 0.551). In the fourth week after treatment, 52.69% of the 10% povidone-iodine group and 55.79% of the Clotrimazole group had a good response to treatment (p = 0.644). In the eighth week after treatment, 58.06% of the 10% povidone-iodine group and 64.21% of the Clotrimazole group had a good response to treatment (p = 0.642) In the 12th week after treatment, 76.34% of the 10% povidone-iodine group and 85.26% of the Clotrimazole group had a good response to treatment (p = 0.248).</p><p><strong>Conclusions: </strong>There were no significant differences in the response to between 10% povidone-iodine and Clotrimazole groups in the second, fourth, eighth and twelfths after treatment.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-4"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473514/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Otorhinolaryngology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0045-1810001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: The main treatment of otomycosis has required the use of topical antifungal drops and/or acidifying agents. However, because of the availability issues of antifungal drops in developing countries, treatment with acidifying agents alone is necessary.
Objective: The objective of this study was to compare the efficacy in the treatment of otomycosis using a 10% povidone-iodine and clotrimazole solution.
Methods: Patients with otomycosis were assigned to 10% povidone-iodine group and Clotrimazole group. The patients were evaluated on the response of each group at 1, 2,4 and 8 weeks.
Results: 93 patients were assigned to the 10% povidone-iodine group and 95 patients to the Clotrimazole group. the response to treatment between groups. In the second week after treatment, 37.64% of the 10% povidone-iodine group and 40% of the Clotrimazole group had a good response to treatment (p = 0.551). In the fourth week after treatment, 52.69% of the 10% povidone-iodine group and 55.79% of the Clotrimazole group had a good response to treatment (p = 0.644). In the eighth week after treatment, 58.06% of the 10% povidone-iodine group and 64.21% of the Clotrimazole group had a good response to treatment (p = 0.642) In the 12th week after treatment, 76.34% of the 10% povidone-iodine group and 85.26% of the Clotrimazole group had a good response to treatment (p = 0.248).
Conclusions: There were no significant differences in the response to between 10% povidone-iodine and Clotrimazole groups in the second, fourth, eighth and twelfths after treatment.