Research Progress on the Prognostic Significance of Systemic Immune Inflammation Index in Patients With Resected Colorectal Cancer: A Meta-Analysis.

IF 2.5 4区医学 Q3 GERIATRICS & GERONTOLOGY

Geriatrics & Gerontology International Pub Date : 2025-09-28 DOI:10.1111/ggi.70197

Wenqing Chen, Xiangrui Li, Jiayue Xia, Da Pan, Xiaotian Chen, Guiju Sun

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引用次数: 0

Abstract

Aim: The systemic immune-inflammation index (SII) serves as a prognostic index of survival among cancer patients. SII is calculated based on the counts of lymphocytes, neutrophils, and platelets. This study aimed to conduct a meta-analysis to explore the predictive role of SII in patients who have undergone surgery for colorectal cancer (CRC).

Methods: A comprehensive search of Web of Science, PubMed, the Cochrane Library, and EMBASE databases was performed to include studies published until 12 Dec 2023. The association between SII and overall survival (OS) in CRC patients who had undergone surgery was assessed by hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: A total of 10 studies with 4537 cases published between 2017 and 2023 were included in this meta-analysis. The mean age of the patients was 60.8 years. The pooled result showed that high SII was correlated with poorer OS (HR = 2.21, 95% CI = 1.95-2.49, p < 0.001) and poorer DFS (HR = 2.81, 95% CI = 2.36-3.34, p < 0.001) in CRC patients who underwent surgery. The cut-off value of SII to predict OS would be 550. Subgroup analysis of SII and survival outcomes in CRC confirmed these findings.

Conclusions: SII emerges as a useful tool for prediction of survival outcomes in patients undergoing CRC surgery, especially in the elderly population over 60 years old.

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系统性免疫炎症指数对结直肠癌切除患者预后意义的meta分析研究进展

目的：全身免疫炎症指数（SII）可作为癌症患者生存的预后指标。SII是根据淋巴细胞、中性粒细胞和血小板的计数计算的。本研究旨在进行荟萃分析，探讨SII在结直肠癌（CRC）手术患者中的预测作用。方法：综合检索Web of Science、PubMed、Cochrane Library和EMBASE数据库，纳入2023年12月12日前发表的研究。通过风险比（hr）和95%置信区间（ci）评估接受手术的结直肠癌患者SII与总生存期（OS）之间的关系。结果：2017 - 2023年间发表的10项研究共4537例纳入本荟萃分析。患者平均年龄60.8岁。综合结果显示，高SII与较差的OS相关（HR = 2.21, 95% CI = 1.95-2.49, p）。结论：SII是预测结直肠癌手术患者生存结局的有用工具，特别是在60岁以上的老年人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.