Diagnosis and management of a rare bilateral ovarian mixed germ cell tumor: a case report.

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI:10.3389/fonc.2025.1504231

Xuanling Li, Min You, Xiaoyun Zhang, Jingjing Wei, Guangyao Lin, Qianjue Tang, Lianwei Xu

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引用次数: 0

Abstract

Background: Mixed ovarian malignant germ cell tumors (MOGCTs) are rare neoplasms composed of two or more malignant germ cell components, representing less than 1% of all ovarian germ cell tumors. They primarily affect adolescents and young women, presenting a clinical challenge due to their histologic heterogeneity, potential for recurrence, and the need to balance oncologic safety with fertility preservation.

Case presentation: We reported a 22-year-old woman diagnosed with a four-component MOGCT in the right ovary-comprising yolk sac tumor, immature teratoma, embryonal carcinoma, and dysgerminoma-along with a dysgerminoma component in the left ovary. Considering her age and fertility desire, fertility-sparing surgery was performed, followed by adjuvant BEP chemotherapy. At 12-month follow-up, the patient remained disease-free with regular menstruation and no signs of recurrence.

Conclusion: This case highlights the feasibility of fertility-sparing treatment in patients with complex bilateral MOGCTs. Given the rarity and histological diversity of such tumors, individualized treatment planning, strict staging, and long-term surveillance are essential to optimize clinical outcomes and preserve reproductive potential.

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罕见双侧卵巢混合生殖细胞瘤的诊断与治疗1例。

背景：混合性卵巢恶性生殖细胞肿瘤（mogct）是由两种或两种以上恶性生殖细胞组成的罕见肿瘤，占卵巢所有生殖细胞肿瘤的不到1%。它们主要影响青少年和年轻女性，由于其组织学异质性、复发的可能性以及需要平衡肿瘤安全性和生育能力，因此提出了临床挑战。病例介绍：我们报告了一名22岁的女性，在右卵巢被诊断为四组分MOGCT，包括卵黄囊肿瘤、未成熟畸胎瘤、胚胎癌和生殖细胞异常瘤，并在左卵巢被诊断为生殖细胞异常瘤。考虑到她的年龄和生育愿望，我们进行了保留生育能力的手术，然后进行了辅助的BEP化疗。在12个月的随访中，患者保持无疾病，月经规律，无复发迹象。结论：本病例强调了保留生育能力治疗复杂双侧mogct患者的可行性。鉴于此类肿瘤的罕见性和组织学多样性，个体化治疗计划、严格的分期和长期监测对于优化临床结果和保持生殖潜力至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.