Yvonne Liu, Johann-Georg Hocher, Shujuan Ma, Liang Hu, Huijun Chen, Xiaoli Zhang, Fei Gong, Bernhard K Krämer, Ge Lin, Berthold Hocher
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引用次数: 0
Abstract
Introduction: With ongoing global lifestyle changes and economic development, the prevalence of hyperuricemia has steadily increased. Elevated levels of serum uric acid (SUA) have been linked to gestational diabetes mellitus (GDM); however, this relationship has not yet been specifically evaluated in women undergoing assisted reproductive technology (ART). Therefore, this study aimed to analyze the relationship between pre-pregnancy SUA as well as SUA to serum creatinine (SCr) ratio and GDM in women undergoing ART.
Methods: This retrospective cohort study was carried out at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, Hunan, China, and included 1027 women who underwent their first ART treatment between 2017 and 2018. SUA levels were measured during the baseline visit prior to any ART procedures, and GDM incidence was recorded based on screening results from the oral glucose tolerance test.
Results: GDM was diagnosed in 172 (16.7%) of the 1027 patients. When comparing SUA quintiles, significant differences were observed in GDM incidence, and several other parameters (including pre-pregnancy weight, BMI, blood glucose, blood pressure, SCr, lipid parameters, anti-Müllarian Hormone, follicle stimulating hormone, and testosterone). SUA was independently associated with GDM incidence after adjusting for potential confounding factors in multivariate analysis (OR 1.004, p = 0.003). Moreover, the SUA/SCr ratio displayed an even stronger association (OR 1.226, p = 0.003).
Conclusion: Pre-pregnancy SUA levels - and particularly the SUA/SCr ratio - were significantly associated with GDM among women undergoing ART.
导读：随着全球生活方式的改变和经济的发展，高尿酸血症的患病率稳步上升。血清尿酸（SUA）水平升高与妊娠期糖尿病（GDM）有关；然而，这种关系尚未在接受辅助生殖技术（ART）的妇女中得到具体评估。因此，本研究旨在分析ART妇女孕前SUA及SUA与血清肌酐（SCr）比值和GDM的关系。方法：本回顾性队列研究在中国湖南省长沙市湘雅生殖与遗传医院开展，纳入了2017年至2018年首次接受ART治疗的1027名女性。在接受任何ART治疗前的基线访问期间测量SUA水平，并根据口服葡萄糖耐量试验的筛查结果记录GDM发病率。结果：1027例患者中有172例（16.7%）诊断为GDM。在比较SUA五分位数时，观察到GDM发生率和其他几个参数（包括孕前体重、BMI、血糖、血压、SCr、脂质参数、抗 llarian激素、促卵泡激素和睾酮）的显著差异。在多因素分析中调整潜在混杂因素后，SUA与GDM发病率独立相关（OR 1.004, p = 0.003）。此外，SUA/SCr比显示出更强的相关性（OR 1.226, p = 0.003）。结论：妊娠前SUA水平——尤其是SUA/SCr比值——与接受ART治疗的女性的GDM有显著相关性。
期刊介绍：
Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series.
In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology.
Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
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