Structural analysis of polysaccharides of the genus Angelica and an overview of their biological activity.

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2025-09-26 DOI:10.1016/j.carres.2025.109689

Xin-Ai Li, Mingyang Cao, Zhi-Min Jian, Fang-Yu Li, Yong-Hui Rui, Ai-En Tao

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引用次数: 0

Abstract

Angelica sinensis (Oliv.) Diels, a perennial herbaceous plant belonging to the Umbelliferae family, is a traditional Chinese medicine commonly used for nourishing blood. The primary bioactive components of Angelica sinensis are polysaccharides, which exhibit various biological functions, including anti-inflammatory, anti-tumor, antioxidant, liver-protective, immune-regulating, and hematopoietic activities. Although numerous studies exist on Angelica polysaccharides, significant knowledge gaps remain regarding genus Angelica polysaccharides (GAPs) isolation, biological activity, structure-activity relationships (SARs), and diverse application potentials. This somewhat hinders the application of GAPs in clinical and market industrialization processes. This article aims to explore and summarize the research progress of GAPs in extraction, separation, purification, structural characteristics, biological activity, and structure-activity relationships, and to examine and emphasize potential application areas and future research directions. This review helps to fill the knowledge gap between theoretical insights and practical applications, guiding future research and industrial applications of GAPs.

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当归属多糖的结构分析及其生物活性综述。

当归（白芷）Diels是一种多年生草本植物，属于伞形科，是一种常用的补血中药。当归的主要生物活性成分为多糖，具有抗炎、抗肿瘤、抗氧化、保护肝脏、调节免疫和造血等多种生物学功能。虽然对当归多糖的研究很多，但在当归多糖属（gaps）的分离、生物活性、构效关系（sar）以及多种应用潜力等方面仍存在很大的知识空白。这在一定程度上阻碍了gap在临床和市场产业化过程中的应用。本文旨在探讨和总结gap在提取、分离、纯化、结构特性、生物活性、构效关系等方面的研究进展，并对其潜在的应用领域和未来的研究方向进行探讨和强调。本文的综述有助于填补gap理论见解与实际应用之间的知识空白，指导gap未来的研究和工业应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".