Association of Serum Uric Acid and CRP/Albumin Ratio With Contrast-Induced Nephropathy in Acute Myocardial Infarction Patients.

IF 2.2 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2025-09-29 DOI:10.1177/00033197251376082

Arzu Akgül, Çağatay Tunca, Alperen Taş, Mehmet Deniz Aylı

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Abstract

Contrast-induced nephropathy (CIN) significantly increases morbidity and mortality among acute myocardial infarction (MI) patients undergoing coronary angiography (CAG). This study evaluated the predictive value of serum uric acid (SUA) and C-reactive protein/albumin ratio (CAR) for CIN development. A retrospective analysis included 1326 acute MI patients who underwent CAG between November 2022 and January 2024. CIN occurred in 119 patients (9.0%). Higher SUA (5.60 vs 4.60 mg/dL, P < .001) and CAR (2.79 vs 2.15, P = .004) were significantly associated with CIN. Multivariate analysis confirmed SUA (Odds Ratio [OR]: 1.577, P < .001) and contrast volume (OR: 1.014, P < .001) as independent predictors. Receiver Operating Characteristic (ROC) analysis identified optimal SUA cutoff at 4.9 mg/dL (sensitivity 67.7%, specificity 68.1%). The predictive value of SUA was stronger among diabetic patients. Additionally, SUA positively correlated with CAR (r = .41, P < .001). A simplified risk score incorporating SUA, CAR, contrast volume, diabetes, and age effectively stratified CIN risk. Elevated SUA levels and high CAR independently predict CIN in acute MI patients, enhancing clinical risk stratification and guiding preventive strategies.

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血清尿酸和CRP/白蛋白比值与急性心肌梗死患者造影剂肾病的关系

造影剂肾病（CIN）在接受冠状动脉造影（CAG）的急性心肌梗死（MI）患者中显著增加发病率和死亡率。本研究评估了血清尿酸（SUA）和c反应蛋白/白蛋白比（CAR）对CIN发展的预测价值。回顾性分析包括在2022年11月至2024年1月期间接受CAG的1326例急性心肌梗死患者。CIN发生119例（9.0%）。高SUA (5.60 vs 4.60 mg/dL, P =。004)与CIN显著相关。多因素分析证实SUA(优势比[OR]: 1.577, P P r =。41岁的P

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days