The Potential of Resveratrol as an Anticancer Agent: Updated Overview of Mechanisms, Applications, and Perspectives.

IF 3.6 3区 医学 Q2 CHEMISTRY, MEDICINAL
Md Rezaul Islam, Rahaf Ajaj, Abdur Rauf, Sanzida Sharmin Shanta, Md Ibrahim Khalil Al-Imran, Md Naeem Hossain Fakir, Alessandra Gianoncelli, Giovanni Ribaudo
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引用次数: 0

Abstract

The natural polyphenol resveratrol, found in several plants, has garnered significant interest due to its beneficial effects on health and for its potential anticancer properties. Studies have demonstrated that it can alter various signaling pathways linked to cancer development and that it inhibits tumor development and spread by exerting several antiproliferative, proapoptotic, anti-inflammatory, and antiangiogenic mechanisms. Its role in regulating oxidative stress and epigenetic modifications further enhances its therapeutic potential. Nevertheless, despite promising preclinical results, clinical translation is to some extent limited by bioavailability, metabolism, and dosage. This updated review explores the mechanisms, also from a structural point of view, behind the anticancer properties of resveratrol, focusing on its impact on crucial signaling networks in different cancer models. Additionally, it overviews the current limitations of resveratrol-based treatments and suggests potential improvements through innovative delivery methods, drug combination approaches, and development of new derivatives. This review was conceived as an update with respect to contributions already present in the literature, thus particular attention has been dedicated to the contribution reported in the literature within the last 5 years and to these studies reporting in vivo data.

白藜芦醇作为抗癌药物的潜力:机制、应用和前景的最新综述。
在几种植物中发现的天然多酚白藜芦醇因其对健康的有益作用和潜在的抗癌特性而引起了人们的极大兴趣。研究表明,它可以改变与癌症发展相关的各种信号通路,并通过发挥多种抗增殖、促凋亡、抗炎和抗血管生成机制来抑制肿瘤的发展和扩散。它在调节氧化应激和表观遗传修饰方面的作用进一步增强了其治疗潜力。然而,尽管临床前结果很有希望,但临床翻译在一定程度上受到生物利用度、代谢和剂量的限制。这篇最新的综述也从结构的角度探讨了白藜芦醇抗癌特性背后的机制,重点关注了它对不同癌症模型中关键信号网络的影响。此外,它概述了目前基于白藜芦醇的治疗的局限性,并提出了通过创新的给药方法、药物联合方法和开发新的衍生物的潜在改进。这篇综述被认为是对文献中已经存在的贡献的更新,因此特别关注过去5年文献中报道的贡献以及这些报告体内数据的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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