Formation of substrate-independent antifouling coatings using a tyrosine-conjugated trimethylamine N-oxide derivative (Tyr-TMAO)

IF 3.4 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2025-09-02 DOI:10.1007/s13233-025-00447-x

Jaesik Yang, Yubin Hong, Suho Park, Daeun Chu, Daewha Hong

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Abstract

Trimethylamine N-oxide (TMAO), which is a naturally occurring osmolyte in marine organisms, has recently attracted attention as a zwitterionic building block for antifouling materials due to its strong hydration capabilities via hydrogen bonding. To translate this hydration-driven behavior into a practical coating strategy, a bioinspired material was designed based on the synthesis of a tyrosine-conjugated TMAO derivative (Tyr-TMAO). Upon enzymatic oxidation by tyrosinase, Tyr-TMAO spontaneously forms superhydrophilic films on a wide range of substrates under aqueous conditions, without the requirements for chemical oxidants. The resulting coatings exhibited excellent antifouling performances, effectively preventing fibrinogen adsorption and NIH 3T3 cell adhesion. This water-based, single-step approach based on enzymatic catalysis offers a broad substrate compatibility and highlights the potential of Tyr-TMAO coatings for use in marine antifouling, biomedical devices, and biosensing applications.

Graphical Abstract

A tyrosine-conjugated TMAO derivative (Tyr-TMAO) was synthesized, whose enzymatic oxidation under aqueous conditions led to the formation of poly(Tyr-TMAO) films on a wide range of substrates. The resulting films exhibited effective antifouling performances against both protein adsorption and cell adhesion.

Abstract Image

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酪氨酸共轭三甲胺n -氧化物衍生物（Tyr-TMAO）形成与底物无关的防污涂料

三甲胺n -氧化物（TMAO）是一种天然存在于海洋生物中的渗透物，由于其通过氢键形成的强大水合能力，近年来作为一种两性离子防污材料引起了人们的关注。为了将这种水合驱动行为转化为实用的涂层策略，基于酪氨酸共轭TMAO衍生物（Tyr-TMAO）的合成设计了一种仿生材料。在酪氨酸酶的酶促氧化作用下，Tyr-TMAO在水条件下自发地在各种底物上形成超亲水性薄膜，而不需要化学氧化剂。该涂层具有优异的防污性能，可有效防止纤维蛋白原吸附和NIH 3T3细胞粘附。这种基于酶催化的水基单步方法提供了广泛的底物兼容性，并突出了tmao涂层在海洋防污、生物医学设备和生物传感应用中的潜力。摘要合成了酪氨酸共轭TMAO衍生物（Tyr-TMAO），其在水条件下的酶促氧化导致在广泛的底物上形成聚（Tyr-TMAO）薄膜。所得膜对蛋白质吸附和细胞粘附均表现出有效的防污性能。

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.