A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment.

IF 26.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Chaoqiang Qiao,Lexuan Wang,Ruili Zhang,Yichenxi Shi,Chuting Huang,Yu Ji,Zuo Yang,Yanbin Feng,Zhuang Chen,Jia Liu,Peng Yang,Zhongliang Wang
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Abstract

Hydrogen sulfide (H2S) exhibits a Janus-faced nature in the regulation of inflammatory diseases, acting as both a therapeutic agent and a pathological aggravator. Effectively harnessing its beneficial effects while mitigating its harmful impacts is pivotal for advancing H2S-based therapies. Here, an innovative H2S supply system is introduced that enables H2S to primarily exhibit its therapeutic effects. Unlike conventional synthetic H2S donor-based strategies, a biomimetic H2S supply system (termed CP) is presented that mimics endogenous enzymatic H2S production. The CP sustainably produces H2S at a constant rate throughout the dosing period, ensuring therapeutic benefits while avoiding toxicity. Furthermore, by functionalizing CP with hyaluronic acid, the resulting system (CPH) not only achieves targeted delivery to inflammatory bowel disease (IBD) tissues but also provides controllable H2S production within the diseased microenvironment. Consequently, CPH significantly mitigates immune inflammation, promotes intestinal epithelial barrier repair, and modulates gut microbiota by sustainably and constantly supplying the multifunctional H2S. This study revolutionizes the H2S supply strategies and provides new insights into gas-based therapies.
促进炎性疾病治疗的仿生硫化氢系统
硫化氢(H2S)在炎症性疾病的调节中表现出两面性,既是治疗剂又是病理加重剂。有效利用其有益影响,同时减轻其有害影响,是推进h2s疗法的关键。在这里,介绍了一种创新的H2S供应系统,使H2S能够主要展示其治疗效果。与传统的基于供体的合成H2S策略不同,提出了一种模拟内源性酶促H2S生产的仿生H2S供应系统(称为CP)。在整个给药期间,CP持续以恒定速率产生H2S,确保治疗效果,同时避免毒性。此外,通过透明质酸功能化CP,所产生的系统(CPH)不仅实现了对炎症性肠病(IBD)组织的靶向递送,而且还在患病微环境中提供了可控的H2S生产。因此,CPH显著减轻免疫炎症,促进肠上皮屏障修复,并通过持续不断地提供多功能H2S来调节肠道微生物群。这项研究彻底改变了H2S的供应策略,并为基于气体的疗法提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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