Dementia prevalence in the Wisconsin Longitudinal Study

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-29 DOI:10.1002/alz.70714

Victoria J. Williams, Ralph Trane, Kamil Sicinski, Carol Roan, Kate Lange, Kerryann DiLoreto, Brittani Strait, Anne Fischer, Grete Wichmann, Garrett Wartenweiler, Nicole Cooke, Emma Henning, Sterling C. Johnson, Michal Engelman, Pamela Herd, Sanjay Asthana

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引用次数: 0

Abstract

INTRODUCTION

While there is growing appreciation of the importance of sociobiological determinants of dementia, few lifespan cohorts offer well-characterized dementia outcomes to explore these aims. We sought to identify dementia prevalence in the Wisconsin Longitudinal Study (WLS), one of the most comprehensive lifespan cohort studies in the United States.

Highlights

We found dementia prevalence in the WLS to be 8.9% when this large population-based cohort was sampled at a mean age of 81.
Of the identified dementia cases, 79% were clinically determined to be due to a presumed underlying etiology of AD.
The targeted multiphased assessment approach used to classify dementia in WLS will be iteratively repeated over time to capture new dementia incidence, complemented by parallel efforts to link WLS with Medicare claims data to identify additional dementia cases among non-respondents or those not selected into the ILIAD sampling frame.
Ongoing data collection efforts include in-home blood collection efforts to characterize plasma levels of AD biomarkers in the WLS cohort.
When resultant dementia classifications are combined with the robust prospectively collected life course data covering a wide array of socioeconomic, educational, occupational, social, behavioral, and physical health variables, the WLS dataset offers an unparalleled opportunity to investigate the sociobiological determinants of late-life dementia.

METHODS

Using a targeted multiphased assessment approach, participants were first screened for dementia risk using a phone-based cognitive assessment. Those scoring below cut-off underwent additional cognitive/medical assessment to determine a consensus-based cognitive diagnosis and suspected underlying etiology.

RESULTS

Cognitive status was determined for 5414 participants, with a dementia prevalence of 8.9% when assessed at a mean age of 81 years.

DISCUSSION

The WLS offers prospectively collected data covering nearly every facet of participant's lives from high school to late life. When combined with newly defined dementia outcomes, the WLS dataset offers a valuable resource to explore full life course determinants of dementia.

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威斯康星纵向研究中的痴呆患病率。

虽然人们越来越认识到痴呆的社会生物学决定因素的重要性，但很少有寿命队列提供明确表征的痴呆结果来探索这些目标。我们试图在威斯康星纵向研究（WLS）中确定痴呆的患病率，这是美国最全面的寿命队列研究之一。我们发现，在这个以人群为基础的大队列中，平均年龄为81岁的WLS人群的痴呆患病率为8.9%。在已确定的痴呆病例中，临床上确定79%是由于假定的AD潜在病因所致。用于对WLS中的痴呆症进行分类的有针对性的多阶段评估方法将随着时间的推移反复重复，以捕获新的痴呆症发病率，并辅以将WLS与医疗保险索赔数据联系起来的平行努力，以识别非应答者或未入选ILIAD抽样框架的人中的额外痴呆症病例。正在进行的数据收集工作包括家庭血液收集工作，以表征WLS队列中AD生物标志物的血浆水平。当所得到的痴呆症分类与涵盖广泛的社会经济、教育、职业、社会、行为和身体健康变量的强大的前瞻性收集的生命历程数据相结合时，WLS数据集提供了一个无与伦比的机会来研究老年痴呆症的社会生物学决定因素。方法采用有针对性的多阶段评估方法，参与者首先使用基于手机的认知评估筛查痴呆风险。得分低于临界值的患者接受额外的认知/医学评估，以确定基于共识的认知诊断和疑似潜在病因。结果5414名参与者的认知状态被确定，当平均年龄为81岁时，痴呆患病率为8.9%。WLS提供了前瞻性收集的数据，涵盖了参与者从高中到晚年生活的几乎每一个方面。当与新定义的痴呆症结果相结合时，WLS数据集为探索痴呆症的整个生命过程决定因素提供了宝贵的资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.