Gestational exposure to poly/perfluoroalkyl substances and risk of congenital structural malformations: A nested case-control study.

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Yanhong Wu, Yilin Lv, Shuang Ran, Wanqin Xie, Haiyan Zhou, Ziwei Zhang, Huamin Yuan, Xingli Li
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Abstract

Congenital structural malformations (CSM) have become a significant public health and social issue, affecting the health status of children and the level of population quality. Emerging research increasingly suggests that environmental pollutants may contribute to the development of CSM. However, current epidemiologic evidence on the effects of per- and polyfluoroalkyl substances (PFAS) on CSM is limited and restrictive. A nested case-control study examined how maternal exposure to PFAS during pregnancy affects the risk of CSM. Logistic regression and Bayesian kernel machine regression (BKMR) were used to assess the effects of single PFAS and PFAS mixture exposure on CSM. Perfluorodecanoic acid (PDA) showed a strong positive association with CSM in the logistic regression model (Adjusted OR: 4.79, 95% CI: 1.55 ~ 18.52). The BKMR analysis indicated an increased risk of CSM as PFAS mixture levels rose above the 55th percentile. Individual PFAS were ranked by posterior inclusion probabilities (PIPs), with PDA (PIP = 1.00), perfluorooctanoic acid (PFOA) (PIP = 1.00), potassium 9-chlorohexadecafluoro-3-oxanonane-1-sulfonate (9Cl_PF3ONS) (PIP = 0.88), and perfluorononanoic acid (PFNA) (PIP = 0.82) contributing most to the mixture's effect on CSM. No significant interactions were observed between PFAS mixtures when other exposures were held constant at the 50th percentile. In conclusion, we found that prenatal exposure to PDA and PFAS mixtures was significantly linked to a heightened risk of CSM, with PDA, PFOA, 9Cl_PF3ONS, and PFNA being significant contributors to the mixture effect. In addition, our study did not identify any previous interactions of PFAS.

妊娠期接触多氟/全氟烷基物质与先天性结构畸形风险:巢式病例对照研究
先天性结构畸形已成为一个重大的公共卫生和社会问题,影响着儿童的健康状况和人口素质水平。越来越多的新研究表明,环境污染物可能促进了CSM的发展。然而,目前关于全氟烷基和多氟烷基物质(PFAS)对CSM影响的流行病学证据是有限和限制性的。一项巢式病例对照研究调查了母亲在怀孕期间暴露于PFAS如何影响CSM的风险。采用Logistic回归和贝叶斯核机回归(BKMR)评估单一PFAS和混合PFAS暴露对CSM的影响。logistic回归模型显示,全氟癸酸(PDA)与CSM呈正相关(校正OR: 4.79, 95% CI: 1.55 ~ 18.52)。BKMR分析表明,当PFAS混合物水平超过第55个百分位时,CSM的风险增加。通过后验包涵概率(PIP)对各个PFAS进行排序,其中PDA (PIP = 1.00)、全氟辛酸(PFOA) (PIP = 1.00)、9-氯六氟-3-草氧酮-1-磺酸钾(9Cl_PF3ONS) (PIP = 0.88)和全氟壬酸(PFNA) (PIP = 0.82)对混合物对CSM的影响最大。当其他暴露量保持在第50百分位数不变时,PFAS混合物之间没有观察到显著的相互作用。总之,我们发现产前暴露于PDA和PFAS混合物与CSM风险增加显著相关,其中PDA、PFOA、9Cl_PF3ONS和PFNA是混合物效应的重要因素。此外,我们的研究没有发现PFAS之前的任何相互作用。
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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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