{"title":"Recurrent pneumococcal OPSI after splenectomy: The need for optimized vaccination and prophylaxis.","authors":"Masashi Nishiyama, Kyoko Yokota, Akihito Matsuoka, Tatsuya Fujikawa","doi":"10.1016/j.jiac.2025.102819","DOIUrl":null,"url":null,"abstract":"<p><p>Patients are known to be at an increased risk of sepsis post-splenectomy due to encapsulated organisms, such as Streptococcus pneumoniae. This is clinically important, as overwhelming post-splenectomy infection (OPSI) is very serious. Prevention, including vaccination, is recommended. Herein, we describe the case of a patient who survived a second attack of OPSI due to S. pneumoniae, serotype 34, that occurred 8 years after acute pericarditis related to S. pneumoniae-associated OPSI. The patient underwent a splenectomy due to malignant lymphoma and had been vaccinated with PPSV 23, but had not received any additional vaccinations since then. Serotype 34 is not covered by either PPSV23 or PCV13. This case highlights the importance of providing patients who have undergone splenectomy with more optimized vaccines, prophylaxis, and education to prevent OPSI, tailored to their immunocompromised status.</p>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102819"},"PeriodicalIF":1.5000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jiac.2025.102819","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Patients are known to be at an increased risk of sepsis post-splenectomy due to encapsulated organisms, such as Streptococcus pneumoniae. This is clinically important, as overwhelming post-splenectomy infection (OPSI) is very serious. Prevention, including vaccination, is recommended. Herein, we describe the case of a patient who survived a second attack of OPSI due to S. pneumoniae, serotype 34, that occurred 8 years after acute pericarditis related to S. pneumoniae-associated OPSI. The patient underwent a splenectomy due to malignant lymphoma and had been vaccinated with PPSV 23, but had not received any additional vaccinations since then. Serotype 34 is not covered by either PPSV23 or PCV13. This case highlights the importance of providing patients who have undergone splenectomy with more optimized vaccines, prophylaxis, and education to prevent OPSI, tailored to their immunocompromised status.
期刊介绍：
The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.
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