Low Bacteroides abundance is related to endothelial dysfunction in type 2 diabetes.

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-09-25 DOI:10.1016/j.diabres.2025.112915

Yoko Omura-Ohata, Cheol Son, Hisashi Makino, Ryo Koezuka, Mayu Tochiya, Masaki Matsubara, Kyoko Honda-Kohmo, Tamiko Tamanaha, Michio Noguchi, Tsutomu Tomita, Yukako Tastumi, Masanari Kuwabara, Keita Watanabe, Ikuo Kimura, Kiminori Hosoda, Yoshihiro Miyamoto, Satoshi Yasuda

{"title":"Low Bacteroides abundance is related to endothelial dysfunction in type 2 diabetes.","authors":"Yoko Omura-Ohata, Cheol Son, Hisashi Makino, Ryo Koezuka, Mayu Tochiya, Masaki Matsubara, Kyoko Honda-Kohmo, Tamiko Tamanaha, Michio Noguchi, Tsutomu Tomita, Yukako Tastumi, Masanari Kuwabara, Keita Watanabe, Ikuo Kimura, Kiminori Hosoda, Yoshihiro Miyamoto, Satoshi Yasuda","doi":"10.1016/j.diabres.2025.112915","DOIUrl":null,"url":null,"abstract":"Aim: Gut microbiota dysbiosis causes atherosclerosis. Patients with atherosclerosis and type 2 diabetes mellitus (T2D) often have low Bacteroides abundance, potentially increasing atherosclerosis risk. This study investigated the association between low Bacteroides abundance and endothelial dysfunction in patients with T2D.Methods: The relationship between the relative Bacteroides abundance in fecal gut microbiota, assessed by 16S ribosomal RNA analysis, and the reactive hyperemia index (RHI) was investigated in 93 patients with T2D (68 men and 25 women). Clinical parameters, including plasma short-chain fatty acids and inflammatory markers, were also examined. Heatmap analysis compared lower Bacteroides group vs. upper Bacteroides group.Results: Natural log-transformed RHI (Ln-RHI) was positively correlated with Ln-relative Bacteroides abundance (p < 0.05). The low Bacteroides group had a considerably lower Ln-RHI than the high group (p = 0.038). Plasma acetate content was correlated with relative Bacteroides abundance (p = 0.036) but not with Ln-RHI content. The low Bacteroides group tended to have higher high-sensitivity C-reactive protein levels than the high group (p = 0.069). No other bacterial differences between the groups were associated with the RHI.Conclusions: Low Bacteroides abundance is associated with low RHI and may be associated with the risk of atherosclerosis in patients with T2D.","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112915"},"PeriodicalIF":7.4000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.diabres.2025.112915","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: Gut microbiota dysbiosis causes atherosclerosis. Patients with atherosclerosis and type 2 diabetes mellitus (T2D) often have low Bacteroides abundance, potentially increasing atherosclerosis risk. This study investigated the association between low Bacteroides abundance and endothelial dysfunction in patients with T2D.

Methods: The relationship between the relative Bacteroides abundance in fecal gut microbiota, assessed by 16S ribosomal RNA analysis, and the reactive hyperemia index (RHI) was investigated in 93 patients with T2D (68 men and 25 women). Clinical parameters, including plasma short-chain fatty acids and inflammatory markers, were also examined. Heatmap analysis compared lower Bacteroides group vs. upper Bacteroides group.

Results: Natural log-transformed RHI (Ln-RHI) was positively correlated with Ln-relative Bacteroides abundance (p < 0.05). The low Bacteroides group had a considerably lower Ln-RHI than the high group (p = 0.038). Plasma acetate content was correlated with relative Bacteroides abundance (p = 0.036) but not with Ln-RHI content. The low Bacteroides group tended to have higher high-sensitivity C-reactive protein levels than the high group (p = 0.069). No other bacterial differences between the groups were associated with the RHI.

Conclusions: Low Bacteroides abundance is associated with low RHI and may be associated with the risk of atherosclerosis in patients with T2D.

查看原文本刊更多论文

低拟杆菌丰度与2型糖尿病内皮功能障碍有关。

目的：肠道菌群失调导致动脉粥样硬化。动脉粥样硬化和2型糖尿病（T2D）患者通常具有较低的拟杆菌丰度，这可能增加动脉粥样硬化的风险。本研究探讨了T2D患者低拟杆菌丰度与内皮功能障碍之间的关系。方法：对93例T2D患者（男68例，女25例）粪便肠道菌群中拟杆菌（Bacteroides）相对丰度（16S核糖体RNA分析）与反应性充血指数（RHI）的关系进行研究。临床参数，包括血浆短链脂肪酸和炎症标志物，也进行了检查。热图分析比较了下拟杆菌组和上拟杆菌组。结果：自然对数转化RHI （Ln-RHI）与ln相对拟杆菌（Bacteroides）丰度呈正相关（p ）结论：低拟杆菌丰度与低RHI相关，并可能与T2D患者动脉粥样硬化的风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.