Sustained low-level transmission of Zika virus in the community prior to its re-emergence in Malaysia, 2007–2012

IF 2.5 3区医学 Q2 PARASITOLOGY

Acta tropica Pub Date : 2025-09-25 DOI:10.1016/j.actatropica.2025.107852

Nor Azila Muhammad Azami , Meng Ling Moi , Hui-Min Neoh , Boekhtiar Borhanuddin , Saberi Saimun , Rahman Jamal

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引用次数: 0

Abstract

During the region-wide Zika virus (ZIKV) outbreak in 2016, the number of reported ZIKV cases was lower in Malaysia than in the neighbouring countries. This study aimed to determine ZIKV seroprevalence in healthy Malaysian adults aged 30–69 years from 2007 to 2012 before the region-wide ZIKV outbreak in 2016. The study participants were recruited between 2007 and 2012 from The Malaysian Cohort project. Zika IgM and IgG reactivities in the serum samples were determined by using the DPP® Zika IgM/IgG Assay System and validated using the ELISA and plaque reduction neutralization test assays. From 913 subjects, 2.0 % and 1.1 % subjects were found to be probable Zika seropositive and Zika seropositive, respectively. In probable Zika seropositive, there is significant differences in seroprevalence among age group and employment status but none in Zika seropositive. Individuals positive for both Zika and dengue antibodies were more likely to be dengue seropositive, with the detected Zika antibodies likely due to cross-reactive neutralizing activity between flaviviruses. ZIKV circulated in Malaysia at low levels in Malaysia prior to the 2016 region-wide outbreak. The high levels of neutralizing antibodies against dengue probably contributed to low number of ZIKV infection in Malaysia during the 2016 ZIKV outbreak.

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2007-2012年，寨卡病毒在马来西亚重新出现之前在社区持续低水平传播。

在2016年全区域寨卡病毒（ZIKV）暴发期间，马来西亚报告的寨卡病毒病例数低于邻国。本研究旨在确定在2016年区域性寨卡病毒暴发之前，2007年至2012年期间马来西亚30-69岁健康成年人的寨卡病毒血清流行率。研究参与者是在2007年至2012年间从马来西亚队列项目中招募的。采用DPP®Zika IgM/IgG检测系统检测血清样品中的Zika IgM和IgG反应性，并采用ELISA和斑块减少中和试验进行验证。913名受试者中，寨卡病毒血清可能阳性和寨卡病毒血清阳性分别为2.0%和1.1%。在可能的寨卡血清阳性中，不同年龄组和就业状况的血清阳性率存在显著差异，但寨卡血清阳性中无显著差异。寨卡和登革热抗体均呈阳性的个体更有可能呈登革热血清阳性，检测到的寨卡抗体可能是由于黄病毒之间的交叉反应性中和活性。在2016年全区域暴发之前，寨卡病毒在马来西亚以低水平传播。高水平的登革热中和抗体可能导致马来西亚在2016年寨卡病毒暴发期间寨卡病毒感染人数较少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta tropica 医学-寄生虫学

CiteScore

5.40

自引率

11.10%

发文量

383

审稿时长

37 days

期刊介绍： Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.