Tyrosine-conjugated diethylene glycol (Tyr-EG2) as a small-molecule material for universal antifouling surface coatings

IF 2.2 4区 化学
Yubin Hong, Suho Park, Jinwoo Lee, Daeun Chu, Daewha Hong
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Abstract

This paper reports the development of a universal antifouling coating based on a small molecule, tyrosine-conjugated diethylene glycol (Tyr-EG2). Tyrosine, a natural precursor in melanin biosynthesis, undergoes tyrosinase-catalyzed oxidation to initiate film formation on various surfaces. Building on this principle, Tyr-EG2 was designed to form a melanin-mimetic poly(Tyr-EG2) film through enzymatic oxidation under mild aqueous conditions (pH 7.4). In contrast to polymeric systems composed of repeating ethylene glycol and catechol units, which often suffer from batch-to-batch variations owing to their high molecular weight and structural complexity, Tyr-EG2 exhibits a well-defined, low molecular weight, which enables consistent synthesis. Moreover, compared with catechol, the phenol-based structure of Tyr-EG2 provides enhanced resistance to auto-oxidation under ambient conditions. The resulting poly(Tyr-EG2) films exhibited excellent coating capabilities on a wide range of substrates, as well as antifouling properties, reducing nonspecific protein adsorption and marine organism adhesion. This simple, mild, and versatile strategy offers a practical platform for achieving antifouling coatings, which are required in the fields of biosensors, marine equipment, and medical devices.

Abstract Image

酪氨酸偶联二甘醇(Tyr-EG2)作为通用防污表面涂层的小分子材料
本文报道了一种基于小分子酪氨酸共轭二甘醇(Tyr-EG2)的通用防污涂料的研制。酪氨酸是黑色素生物合成的天然前体,经过酪氨酸酶催化氧化,在各种表面形成膜。基于这一原理,tyr1 - eg2被设计成在温和的水条件下(pH 7.4)通过酶氧化形成一种模拟黑色素的聚(tyr1 - eg2)膜。与由重复的乙二醇和儿茶酚单元组成的聚合物体系相反,由于其高分子量和结构复杂性,它们经常遭受批次到批次的变化,Tyr-EG2表现出明确的低分子量,从而实现一致的合成。此外,与儿茶酚相比,Tyr-EG2的酚基结构在环境条件下具有更强的抗自氧化性。所得到的聚Tyr-EG2薄膜在广泛的底物上表现出优异的涂层能力,以及防污性能,减少非特异性蛋白质吸附和海洋生物粘附。这种简单、温和、通用的策略为实现生物传感器、海洋设备和医疗设备领域所需的防污涂层提供了一个实用的平台。
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来源期刊
Bulletin of the Korean Chemical Society
Bulletin of the Korean Chemical Society Chemistry-General Chemistry
自引率
23.50%
发文量
182
期刊介绍: The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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