Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics (Adv. Healthcare Mater. 25/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-09-29 DOI:10.1002/adhm.70236

Nok Yin Tam, Xiaoqi Wang, Grace Chung Yan Chan, Wai Po Kong, Wai Yin Chau, Xiuqiong Fu, Kwok-Yin Wong, Hong Lok Lung, Zhi-Ling Yu, Wei Shen Aik

引用次数: 0

Abstract

Modular RNAi Therapeutics Delivery Platform

In the Research Article, Zhi-Ling Yu, Wei Shen Aik and co-workers present a modular and customizable protein-based RNAi therapeutics delivery platform, called the Sm protein-small interfering ribonucleoprotein complex (SmiRNP). The pseudosymmetric complex allows for modular fusion of multiple protein domains to overcome biological hurdles such as cellular uptake and endosomal escape. The authors demonstrated its feasibility, efficacies, and versatility in delivering siRNA to silence the KRAS oncogene in vitro and in vivo (DOI: 10.1002/adhm.202503281).

Abstract Image

查看原文本刊更多论文

模块化核糖核蛋白复合物的发展作为提供RNAi治疗的一般策略（Adv. Healthcare Mater. 25/2025）

模块化RNAi治疗递送平台在这篇研究文章中，于志玲、沈伟及其同事提出了一种模块化和可定制的基于蛋白质的RNAi治疗递送平台，称为Sm蛋白-小干扰核糖核蛋白复合物（SmiRNP）。假对称复合体允许多个蛋白质结构域的模块化融合，以克服诸如细胞摄取和内体逃逸等生物学障碍。作者证明了其可行性，有效性，以及在体外和体内递送siRNA沉默KRAS致癌基因的多功能性（DOI: 10.1002/ admm .202503281）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.