Two Metals, One Goal: Unlocking Reactivity with Heterobimetallic Systems for Organic Transformations

Abstract

The design of heterobimetallic catalysis is redefining the frontiers in organic synthesis by harnessing the combined power of two distinct metals. It maneuvers a powerful platform in advancing organic transformations through leveraging cooperative synergetic effect of bimetals. In this review, this study unveils heterobimetallic systems that unlock challenging bond activations and novel reaction pathways inaccessible to traditional monometallic systems. It highlights key examples across diverse reaction classes of organic transformation paving way for alkylation, alkenylation, arylation, annulation, cross‐coupling, and oxidative and decarboxylative coupling reactions for the synthesis of pharmaceutically and industrially relevant molecules. The review consolidates on the current updates on the reactions, mechanism, catalytic cycle, and their synthetic transformations. Heterobimetallic catalysts deliver amplified reactivity, expanded substrate diversity, and sharpened selectivity profiles. The bimetallic catalytic system orchestrates multielectron redox‐processes, dual‐site activation, and high turnover numbers. The review concludes with a brief outlook on the future scope, offering a blueprint for next‐generation catalytic platforms that push the boundaries of molecular construction.