Reply: Prevalence of serum HBsAg <100 IU/mL in inactive chronic hepatitis B

Abstract

We appreciate the comments by Fan et al 1 on our recent publication entitled ‘Hepatitis B surface antigen level identifies patients with inactive chronic hepatitis B from Asia with HCC risk below surveillance threshold’.2 They also shared their data from 4386 patients with inactive chronic hepatitis B (CHB), which showed similarities with our findings.1 The authors are particularly interested in the proportion of patients with hepatitis B surface antigen (HBsAg) <100 IU/mL. Among the 2674 patients with inactive CHB from Taiwan, 989 (37.0%) had HBsAg<100 IU/mL, as reported in table 1 of our original article,2 which is close to the 30% …