Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-08-01 Epub Date: 2025-09-24 DOI:10.1016/j.bpsc.2025.09.015

Lucy Vanes, Divyangana Rakesh, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Sarah Hohmann, Nathalie Holz, Christine Macare

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引用次数: 0

Abstract

Background

Adolescence is a critical period of neurodevelopment marked by ongoing maturation of structural and functional brain connectivity. Simultaneously, this period is associated with an increase in mental health problems, spanning from subclinical symptoms to diagnosable disorders.

Methods

This study investigated longitudinal associations between psychopathology dimensions and voxelwise brain measures related to connectivity across 3 time points (ages 14, 19, and 23) in more than 1500 participants using the IMAGEN dataset. White matter (WM) microstructure was indexed using diffusion metrics quantified along the WM skeleton (N = 1736), while functional connectivity was captured as voxelwise degree centrality (DC) derived from resting-state functional imaging (N = 1510).

Results

Development of WM microstructure was selectively linked to externalizing (but not internalizing) symptoms. Here, higher externalizing symptoms were associated with widespread reductions in fractional anisotropy (FA) across the WM skeleton as well as accelerated decreases in FA in the corticospinal tract over time. In contrast, functional DC was developmentally associated with general, rather than specific, psychopathology in frontal and temporal regions. An increase in total difficulties over time was associated with developmental decrease in DC in bilateral superior frontal gyri. In addition, a positive association between total difficulties and DC in left inferior temporal gyrus was observed in younger, but not older, adolescents or young adults.

Conclusions

These findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of development.

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结构和功能脑连接与青少年精神病理维度的纵向关联。

背景：青春期是神经发育的关键时期，标志着大脑结构和功能连接的不断成熟。同时，这一时期与心理健康问题的增加有关，从亚临床症状到可诊断的疾病。方法：本研究使用IMAGEN数据集调查了1500多名个体在三个时间点（14岁、19岁和23岁）的精神病理维度和脑体素测量之间的纵向关联。通过沿白质（WM）骨架量化的扩散指标（N = 1736）对白质微观结构进行索引，而通过静息状态功能成像（N = 1510）得出的体素度中心性（DC）捕获功能连通性。结果：WM微结构的发展选择性地与外化（而非内化）症状相关联。在这里，较高的外化症状与整个WM骨骼的分数各向异性（FA）的广泛减少以及皮质脊髓束FA随时间的加速减少有关。相反，功能性DC在发育上与额叶和颞叶区域的一般精神病理相关，而不是特定的。随着时间的推移，总困难的增加与双侧额上回DC的发育减少有关。此外，总的困难与左颞下回DC之间的正相关在年轻人中被观察到，但在老年人、青少年或年轻人中没有。结论：这些发现强调了青春期大脑连接发展与精神病理之间的动态相互作用，对识别发育敏感窗口期的风险和弹性神经标志物具有潜在的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.