Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system.

IF 4.1 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES
Miriam Capri, Nicola Montano, Sara Piccirillo, Marco Narici, Francesca Ferranti, Mauro Maccarrone
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引用次数: 0

Abstract

Spaceflight missions represent a new exposome, unpredicted by evolution. Life-threatening agents activate non-specific stress responses involving the psycho-immune-neuroendocrine network. The main molecular pathways regulating this network and those affected by spaceflight exposome/microgravity are reported in various experimental setups. They include gut microbiota-derived metabolites, potentially valuable for countermeasure development. Meaningfully, the application of neuromodulation techniques, like the non-invasive transcutaneous vagal stimulation, for the prevention of pathophysiological alterations related to stress responses, is discussed.

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航天暴露/微重力对心理免疫神经内分泌系统的影响。
太空飞行任务代表了一种新的暴露,是进化无法预测的。危及生命的药物激活涉及心理-免疫-神经内分泌网络的非特异性应激反应。在各种实验装置中报道了调节该网络的主要分子途径以及受航天暴露/微重力影响的分子途径。它们包括肠道微生物衍生的代谢物,对对策开发具有潜在价值。有意义的是,讨论了神经调节技术的应用,如非侵入性经皮迷走神经刺激,以预防与应激反应相关的病理生理改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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