Virome Analysis of Small Mammals from the Brazilian Amazon.

IF 3.5 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2025-09-16 DOI:10.3390/v17091251

Leonardo Henrique Almeida Hernández, Fábio Silva da Silva, Thito Yan Bezerra da Paz, Daniel Damous Dias, Bruno de Cássio Veloso de Barros, Bruno Tardelli Diniz Nunes, Lívia Medeiros Neves Casseb, Sandro Patroca da Silva, Pedro Fernando da Costa Vasconcelos, Ana Cecília Ribeiro Cruz

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Abstract

The municipalities of Peixe-Boi and Santa Bárbara do Pará, both in the Pará State (eastern Amazon), have more than half of their territory deforested. Understanding the viral diversity in wildlife that inhabits the surroundings of human communities contributes to strengthening surveillance. Samples from eleven bats, seven opossums, and eight rodents from the two locations were screened by high-throughput sequencing for virome analysis. Viral reads were assigned into twenty viral families, from which the most abundant was Retroviridae. Host order, tissue type, and season showed a significant effect on viral composition. Five viral genomes of bat ERVs with intact genes were recovered, showing the need to understand their endogenous nature. In addition, a new Buritiense virus (Hantaviridae) strain was also obtained, supporting its circulation in Santa Bárbara do Pará and expanding its genomic information. Together, these findings reinforce the need for continuous surveillance in wild animals, especially in the Amazon region, to anticipate potential threats to public health.

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巴西亚马逊地区小型哺乳动物的病毒组分析。

位于帕尔州（亚马逊东部）的pexe - boi市和Santa Bárbara do par市有一半以上的领土被砍伐。了解生活在人类社区周围的野生动物的病毒多样性有助于加强监测。采用高通量测序技术对来自两个地点的11只蝙蝠、7只负鼠和8只啮齿动物样本进行病毒组分析。病毒reads被划分为20个病毒科，其中最丰富的是逆转录病毒科。宿主顺序、组织类型和季节对病毒组成有显著影响。恢复了5个完整基因的蝙蝠erv病毒基因组，表明需要了解其内源性性质。此外，还获得了一种新的布里itiense病毒（汉坦病毒科）毒株，支持其在Santa Bárbara do par的传播，并扩展了其基因组信息。总之，这些发现加强了对野生动物进行持续监测的必要性，特别是在亚马逊地区，以预测对公众健康的潜在威胁。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.