Porcine Parvovirus in China: Recent Advances, Epidemiology, and Vaccine Strategies.

IF 3.5 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2025-09-18 DOI:10.3390/v17091262

Yunchao Liu, Yumei Chen, Yanli Shang, Xiuli Deng, Huifang Hao

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Abstract

Porcine parvovirus (PPV), a non-envelope single-stranded DNA virus, causes severe reproductive disorders in swine worldwide, characterized by fetal mortality, mummification, and reduced boar fertility. As a highly prevalent pathogen in Chinese swine herds, PPV imposes substantial economic burdens on intensive pig production systems. This review systematically synthesizes recent advances in PPV virology, focusing on genomic evolution of emerging strains (PPV1-PPV8), epidemiological dynamics of emerging strains, molecular pathogenesis, and novel diagnostic tools. Furthermore, we critically evaluate current vaccine strategies, highlighting their limitations in cross-protective efficacy and viral shedding control. By integrating multi-omics insights with immunological profiling, this work delineates actionable pathways for next-generation vaccine design and proposes a roadmap for rational antigen selection. This review consolidates foundational knowledge and establishes a translational bridge between basic virology and prevention and control of porcine parvovirus, addressing critical gaps in porcine reproductive disease management.

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中国猪细小病毒：最新进展、流行病学和疫苗策略。

猪细小病毒（PPV）是一种非包膜单链DNA病毒，在世界范围内引起猪严重的生殖障碍，其特征是胎儿死亡、木乃伊化和猪生育能力下降。PPV作为中国猪群中高度流行的病原体，给集约化养猪生产系统带来了巨大的经济负担。本文系统地综述了PPV病毒学的最新进展，重点介绍了新出现菌株（PPV1-PPV8）的基因组进化、新出现菌株的流行病学动态、分子发病机制和新的诊断工具。此外，我们批判性地评估了当前的疫苗策略，强调了它们在交叉保护功效和病毒脱落控制方面的局限性。通过将多组学见解与免疫学分析相结合，这项工作描绘了下一代疫苗设计的可行途径，并提出了合理抗原选择的路线图。这篇综述巩固了基础知识，并在猪细小病毒的基础病毒学和预防和控制之间建立了一座转化桥梁，解决了猪生殖疾病管理的关键空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.