Velia Chiara Di Maio, Rossana Scutari, Martina Mastropaolo, Luna Colagrossi, Giulia Linardos, Luana Coltella, Stefania Ranno, Eugenia Galeno, Mara Pisani, Anna Chiara Vittucci, Sebastian Cristaldi, Massimiliano Raponi, Alberto Villani, Cristina Russo, Carlo Federico Perno
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引用次数: 0
Abstract
Background: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARIs) in children. However, the clinical impact of RSV co-infection with other respiratory viruses remains unclear. This study investigates the frequency and clinical outcomes of RSV infections in a large paediatric cohort.
Methods: Paediatric patients with RSV-positive respiratory samples admitted to Bambino Gesù Children's Hospital between January 2022 and April 2024 were analysed.
Results: Within 17,259 respiratory samples from 9877 paediatric patients, 952 (9.6%) were RSV-positive. Among these, 637 patients with ARI were included. RSV affected the lower respiratory tract in 549 cases (86.2%) and the upper tract in 88 (13.8%) cases. RSV mono-infection was found in 286 (44.9%) patients, while 351 (55.1%) patients had co-infections. Mono-infections showed lower cycle-threshold (CT) than co-infections in both upper and lower tract (p-value:0.002 and 0.037, respectively). Pneumonia was associated with RSV co-infection (N = 48, 15.4%), whereas bronchiolitis was mostly seen in mono-infection (N = 196, 78.1%, p-value:0.002). Regression analysis showed an association between pneumonia and co-infection (AOR: 1.97 [1.06-3.64], p-value = 0.031), higher CT (AOR [95% CI]: 1.07 [1.02-1.11], p-value = 0.006) and older age (AOR [95% CI]: 1.48 [1.31-1.68], p-value < 0.001), whereas bronchiolitis was associated with mono-infection, younger age and lower CT.
Conclusions: This study highlights the role of RSV in paediatric disease and emphasises the importance of early diagnosis, personalised treatment and preventive strategies to improve outcomes and reduce the burden of disease.
期刊介绍：
Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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