Exchange Transfussion for the Treatment of Severe Indirect Hyperbilirubinemia Caused by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report.

IF 0.6 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2025-09-27 DOI:10.1080/15513815.2025.2565690

Hatice Buket Özay, Melek Tandoğan, Bayram Ali Dorum, Erbu Yarcı

引用次数: 0

Abstract

Hyperbilirubinemia is a common problem during the neonatal period, which can lead to high morbidity and mortality if it is not treated properly. The most common first-line treatment used for hyperbilirubinemia is phototherapy. Glucose-6-phosphate dehydrogenase deficiency (G6PD) can cause indirect hyperbilirubinemia not only with hemolysis but also by affecting bilirubin metabolism in the liver during the neonatal period. In here, we report a three-day-old newborn with severe hyperbilirubinemia who underwent exchange transfusion with a diagnosis of G6PD deficiency to emphasize the importance of keeping in mind erythtocyte enzyme defects in the differential diagnosis of severe indirect hyperbilirubinemia.

查看原文本刊更多论文

交换输注治疗葡萄糖-6-磷酸脱氢酶缺乏所致严重间接高胆红素血症1例。

高胆红素血症是新生儿期的常见问题，如果治疗不当，可导致高发病率和死亡率。高胆红素血症最常用的一线治疗方法是光疗。葡萄糖-6-磷酸脱氢酶缺乏症（G6PD）可引起间接高胆红素血症，不仅伴有溶血，而且影响新生儿肝脏胆红素代谢。在这里，我们报告了一个3天大的新生儿严重高胆红素血症，他接受了换血，诊断为G6PD缺乏症，以强调在严重间接高胆红素血症的鉴别诊断中牢记红细胞酶缺陷的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.