Frailty in Spontaneous Intracerebral Haemorrhage and its Outcomes: A Systematic Review and Meta-Analysis.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-09-24 DOI:10.1016/j.wneu.2025.124503

Claire Yi Jia Lim, Lucas Tze Peng Tan, Jin Hean Koh, Mervyn Jun Rui Lim, Li Feng Tan

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引用次数: 0

Abstract

Background: Frailty has been shown to be a better predictor of clinical outcomes than age alone across many diseases. Few studies have evaluated the association of frailty and SICH incidence and outcomes. The aim of this systematic review and meta-analysis was to investigate the odds of frailty in SICH and the prognosis of SICH patients who are frail.

Methods: Following a PROSPERO-registered protocol, three authors conducted a systematic review of the PubMed/Medline, Embase, Cochrane Library and CINAHL databases up to 17 October 2024. The certainty of evidence was assessed using the GRADE framework. A standard pairwise meta-analysis using odds ratios and 95% confidence intervals was performed, with results presented in forest plots.

Results: From 8 included studies (17, 524 participants), the odds of frailty are significantly higher in SICH patients than patients without SICH (OR: 1.47, 95% CI: 1.31 to 1.64, p < 0.01). Within the SICH cohort, frail patients have significantly higher rates of mortality (OR: 3.48, 95% CI: 2.51 to 4.82, p < 0.01) and unfavourable outcome (mRS 3-6) (OR: 1.75, 95% CI: 1.35 to 2.26, p < 0.01) CONCLUSION: SICH patients are more likely to be frail, and SICH patients who are frail have higher rates of mortality and adverse outcomes. Further research is required to compare the robustness of different frailty assessment tools in assessing frailty in SICH cohorts.

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自发性脑出血的衰弱及其结局：系统回顾和荟萃分析。

背景：在许多疾病中，虚弱已被证明比年龄本身更能预测临床结果。很少有研究评估虚弱与siich发病率和预后的关系。本系统综述和荟萃分析的目的是调查SICH中虚弱的几率和虚弱的SICH患者的预后。方法：按照prospero注册方案，三位作者对截至2024年10月17日的PubMed/Medline、Embase、Cochrane Library和CINAHL数据库进行了系统评价。使用GRADE框架评估证据的确定性。采用比值比和95%置信区间进行标准两两荟萃分析，结果呈现在森林样地中。结果：在8项纳入的研究（17,524名受试者）中，SICH患者的衰弱几率显著高于非SICH患者（OR: 1.47, 95% CI: 1.31 ~ 1.64, p < 0.01）。在SICH队列中，体弱患者的死亡率（OR: 3.48, 95% CI: 2.51 ~ 4.82, p < 0.01）和不良结局（mRS 3-6）显著较高（OR: 1.75, 95% CI: 1.35 ~ 2.26, p < 0.01）。结论：SICH患者更容易体弱，体弱的SICH患者死亡率和不良结局更高。需要进一步的研究来比较不同的脆弱性评估工具在评估SICH队列中的脆弱性方面的稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS