Imadh Khan, Hannah E Johnson, Noah B Drewes, Blaine A Traylor, Andre F Catalano, Kristin Delfino, Hayan Dayoub
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引用次数: 0
Abstract
Background: The formation and progression of intracranial aneurysms are influenced by multiple factors. Previous studies have shown the local geometry surrounding an aneurysm to influence its development. The geometry of the global cerebral vasculature, however, and its potential effects on aneurysms have not been well elucidated. We hypothesized that select geometries within the anterior cerebral circulation would differ among those with ruptured and unruptured aneurysms.
Methods: We conducted a retrospective analysis of 38 patients who presented to our institution for catheter-based 3D rotational cerebral angiography for assessment of intracranial aneurysms. Geometric analysis was conducted using Materialise Mimics® and 3-Matic®.
Results: Those with a ruptured aneurysm (n = 7) had a significantly larger bifurcation angle between the ACA and MCA compared to patients with unruptured aneurysms (97.96°, 91.60°, p = 0.01). Subgroup analysis demonstrated larger ACA diameters in the cohort of patients with ACA aneurysms (3.14 mm) compared to those with ICA and MCA aneurysms (2.45 mm, 2.61 mm, p=0.004). Patients over the age of 65 had larger MCA bifurcation angles (94.87°) compared to their younger counterparts (86.58°, p = 0.024). Males exhibited a significantly larger petrous ICA diameter (5.33 mm vs. 4.53 mm, p <0.001), ICA genu diameter (4.97 mm vs. 4.43 mm, p=0.017), and ACA diameter (2.96 mm vs. 2.55 mm, p=0.010), compared to female patients, but a smaller ACA-MCA bifurcation angle (91.11° vs. 94.31°, p = 0.039).
Conclusion: We conclude that geometric differences may be the result of systemic vascular remodeling and a potential indicator of aneurysm integrity.
期刊介绍：
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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