Comparative Genetics of Canine and Human Cancers.

IF 2.3 2区 农林科学 Q2 VETERINARY SCIENCES
Richard Curtis Bird, Bruce F Smith
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引用次数: 0

Abstract

Domestic dogs develop cancer at rates similar to, or greater than, humans and suffer from cancer types that also reflect several similar common types of human disease. Canine cancers have, as a consequence, been investigated as a model of human cancer that is particularly attractive because it is an intermediate sized animal model with an intact immune system that develops spontaneous disease. This discipline has had extraordinary consequences for canine medicine as well, promoting the exploration of the genetics of canine cancers and the development of new therapies designed to be translated to humans but that also benefit the dogs themselves. We review the gene defects found in the most well-studied canine cancers and the new therapeutic approaches such investigations have promoted.

犬类和人类癌症的比较遗传学。
家养狗患癌症的几率与人类相似,甚至高于人类,它们所患的癌症类型也反映了几种类似的人类常见疾病。因此,犬类癌症被研究为人类癌症的模型,这一点特别有吸引力,因为它是一种中等大小的动物模型,具有完整的免疫系统,可以发展为自发疾病。这一学科也对犬类医学产生了非凡的影响,促进了犬类癌症遗传学的探索,以及设计用于人类但也有益于狗本身的新疗法的开发。我们回顾了在大多数研究犬癌症中发现的基因缺陷,以及这些研究所促进的新的治疗方法。
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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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