Xuanbo Shao, Zhuofan Xu, Penghao Liu, Teng Zhang, Yang Feng, Shaxi Zhu, Zan Chen, Wanru Duan
{"title":"TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report.","authors":"Xuanbo Shao, Zhuofan Xu, Penghao Liu, Teng Zhang, Yang Feng, Shaxi Zhu, Zan Chen, Wanru Duan","doi":"10.1186/s12957-025-04003-w","DOIUrl":null,"url":null,"abstract":"<p><p>Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3-marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"344"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466048/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12957-025-04003-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3-marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.
期刊介绍：
World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics.
Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
