Correlates of Meningococcal B Vaccination and Health Behavior Profiles Among MSM in China.

IF 5.2 3区医学 Q1 IMMUNOLOGY

Vaccines Pub Date : 2025-09-19 DOI:10.3390/vaccines13090983

Rongyan Li, Qian Zou, Yi Zhou, Ye Zhang, Dan Wu, Xinyuan Zhang, Fengshi Jing, Jie Fan, Xi He, Weiming Tang

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引用次数: 0

Abstract

Background: Meningococcal B (MenB) vaccination offers protection against invasive meningococcal disease and moderate cross-protection against gonorrhea. However, little is known about coverage and behavioral correlates among men who have sex with men (MSM) in China. This study assessed self-reported MenB vaccination uptake and its associations with sociodemographic and behavioral factors.

Methods: We conducted a nationwide cross-sectional survey among 1022 MSM recruited via community-based organizations and online platforms. Vaccination status and recent sexual behaviors were self-reported. Logistic regression identified correlates of uptake, and latent class analysis (LCA) examined behavioral profiles.

Results: Participants had a mean age of 29.6 years; most were unmarried (87.7%) and nearly 90% had a college degree or above. Overall, 21.7% reported receiving MenB vaccination. Uptake was positively associated with condomless anal intercourse (aOR = 1.57, 95% CI: 1.08-2.31), group sex (occasionally: aOR = 1.63, 95% CI: 1.01-2.64; frequently: aOR = 3.86, 95% CI: 1.85-8.04), and female partners in the past six months (aOR = 3.69, 95% CI: 2.25-6.10). MSM with multiple casual male partners were less likely to be vaccinated (aOR = 0.55, 95% CI: 0.32-0.93). LCA identified heterogeneous subgroups; notably, the "multi-partner and proactive" group, with high pre-exposure prophylaxis against HIV infection awareness and frequent STI testing, showed low uptake (13.4%).

Conclusions: MenB vaccination coverage among MSM in China remained suboptimal. Uptake differed across behavioral subgroups, underscoring the need for stratified, context-specific strategies to inform future vaccine introduction.

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中国男男性行为者接种乙型脑膜炎球菌疫苗与健康行为的相关性

背景：B型脑膜炎球菌（MenB）疫苗接种可预防侵袭性脑膜炎球菌病和对淋病的中度交叉保护。然而，对中国男男性行为（MSM）的覆盖率和行为相关性知之甚少。本研究评估了自我报告的乙型脑膜炎疫苗接种情况及其与社会人口统计学和行为因素的关系。方法：通过社区组织和网络平台对全国1022名男男性行为者进行横断面调查。疫苗接种状况和近期性行为均为自我报告。逻辑回归确定了摄取的相关因素，潜类分析（LCA）检查了行为特征。结果：参与者的平均年龄为29.6岁；大多数人未婚（87.7%），近90%的人拥有大专及以上学历。总体而言，21.7%的人报告接受了b型脑膜炎疫苗接种。摄入与无套肛交（aOR = 1.57, 95% CI: 1.08-2.31）、群体性行为（偶尔：aOR = 1.63, 95% CI: 1.01-2.64；频繁：aOR = 3.86, 95% CI: 1.85-8.04）和过去6个月内的女性伴侣（aOR = 3.69, 95% CI: 2.25-6.10）呈正相关。有多个偶然性男性伴侣的MSM接种疫苗的可能性较低（aOR = 0.55, 95% CI: 0.32-0.93）。LCA鉴定出异质亚群；值得注意的是，“多伴侣和积极主动”组的使用率较低（13.4%），他们对暴露前预防艾滋病毒感染的认识较高，并经常进行性传播感染检测。结论：中国男男性行为者的乙肝疫苗接种率仍不理想。不同行为亚组对疫苗的吸收情况不同，这强调了需要采取分层的、针对具体情况的策略，以便为未来的疫苗引入提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

8.90

自引率

16.70%

发文量

1853

审稿时长

18.06 days

期刊介绍： Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.