A Review of Advances in Lung Function Imaging and Its Applications for Functional Lung Avoidance in Radiation Therapy.

IF 5.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Zhi Chen, Zihan Li, Yu-Hua Huang, Tianyu Xiong, Xinzhi Teng, Bing Li, John Kipritidis, Paul J Keall, Joseph M Reinhardt, Hong Ge, Ge Ren, Jing Cai
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引用次数: 0

Abstract

Lung function imaging, with a specific focus on quantifying ventilation and perfusion, has gained increasing recognition within the field of functional lung avoidance radiation therapy (FLART), a technique that incorporates functional information to minimize radiation exposure to healthy lung tissue. This review critically analyzes multiple categories of clinical imaging modalities, including nuclear medicine imaging, computed tomography, and magnetic resonance imaging, which can assess the spatial distribution of lung functions. Each modality presents unique strengths in providing valuable information for FLART, yet they also have their limitations, which are detailed in this review. Furthermore, we discuss the current challenges limiting the broader implementation of lung function imaging and FLART in clinical practice. Future research directions and potential solutions are also outlined, to enable lung function imaging to play a more significant role in FLART, leading to personalized lung cancer management and improved patient outcomes.

肺功能影像学研究进展及其在放射治疗中肺功能回避的应用。
肺功能成像,特别关注通气和灌注的量化,在功能性肺回避放射治疗(FLART)领域得到了越来越多的认可,FLART是一种结合功能信息的技术,可以最大限度地减少对健康肺组织的辐射暴露。这篇综述批判性地分析了多种临床成像方式,包括核医学成像、计算机断层扫描和磁共振成像,它们可以评估肺功能的空间分布。每种模式在为FLART提供有价值的信息方面都有其独特的优势,但它们也有其局限性,本文将详细介绍这些局限性。此外,我们讨论了目前限制肺功能成像和FLART在临床实践中更广泛实施的挑战。展望了未来的研究方向和可能的解决方案,以使肺功能成像在FLART中发挥更大的作用,从而实现肺癌的个性化治疗和患者预后的改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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