Antimicrobial Evaluation of Chlorophyll-Containing Nettle Extract Both in Free Form and Incorporated into Poly-3-Hydroxybutyrate.

IF 4.9 3区工程技术 Q1 POLYMER SCIENCE

Polymers Pub Date : 2025-09-17 DOI:10.3390/polym17182507

Polina M Tyubaeva, Ivetta A Varyan, Sergei I Obydennyi, Vasily A Merzlikin, Svetlana G Karpova, Olga A Gruznova, Dmitry V Gruznov, Ekaterina N Shuteeva, Nikolay N Kuvshinchikov, Nikolay I Popov, Anton V Lobanov, Ivan A Abramov, Andrey P Sergeev, Anzhelika V Zagaynova, Anatoly A Olkhov

引用次数: 0

Abstract

This work is devoted to the electrospinning of biocompatible fibrous matrixes for microbial wound therapy. The problem of treating staphylococcal-infected wounds remains urgent. In this study, we propose a new approach to the use of the chlorophyll (Chl) and poly-3-hydroxybutyrate (PHB) composite system in the treatment of infected wounds. The structure and properties of the electrospun polymer matrix based on PHB modified with various concentrations of Chl was investigated by SEM, confocal microscopy, DSC, EPR. The release rate, fluorescence, and antimicrobial activity of Chl incorporated into PHB were studied. The high efficiency of the developed materials was shown with the participation of laboratory animals.

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含叶绿素荨麻提取物（游离形式和加入聚3-羟基丁酸酯）的抗菌评价。

这项工作致力于静电纺丝的生物相容性纤维基质微生物伤口治疗。治疗葡萄球菌感染伤口的问题仍然紧迫。在本研究中，我们提出了一种利用叶绿素（Chl）和聚3-羟基丁酸酯（PHB）复合体系治疗感染伤口的新方法。采用SEM、共聚焦显微镜、DSC、EPR等研究了不同浓度Chl修饰的PHB电纺丝聚合物基体的结构和性能。研究了Chl在PHB中的释放率、荧光特性和抗菌活性。实验动物的参与证明了所开发材料的高效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymers POLYMER SCIENCE-

CiteScore

8.00

自引率

16.00%

发文量

4697

审稿时长

1.3 months

期刊介绍： Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.