Vitamin D Genetics Beyond Serum 25(OH)D: VDR rs2228570 (FokI) Polymorphism, Inflammation, and Quality of Life in Orthopedic Patients.

IF 5 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-09-11 DOI:10.3390/nu17182926

Dariusz Larysz, Remigiusz Recław, Aleksandra Suchanecka, Wojciech Dziurawiec, Rafał Tkacz, Aleksandra Strońska-Pluta, Krzysztof Chmielowiec, Anna Grzywacz, Jolanta Chmielowiec

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引用次数: 0

Abstract

Background: Vitamin D receptor (VDR) polymorphisms may influence immune regulation and musculoskeletal health, but their perioperative role is not well understood. This study investigated the rs2228570 (FokI) variant in relation to inflammatory, hematologic, and patient-reported outcomes in orthopedic patients.

Methods: We genotyped 300 orthopedic patients and 200 healthy controls using real-time PCR. Regression models in patients adjusted for age and body mass index (BMI) examined associations between rs2228570 genotypes and laboratory as well as clinical outcomes.

Results: The CC genotype (homozygous cytosine) was associated with higher white blood cell count (β = 0.52, p = 0.0435), higher lymphocyte count (β = 0.26, p = 0.00025), higher hemoglobin (β = 0.57, p = 0.00197), and higher hematocrit (β = 1.42, p = 0.01102). The TT genotype (homozygous thymine) was associated with higher C-reactive protein (β = 10.90, p = 0.00329), lower mean corpuscular volume (β = -1.63, p = 0.04909), and higher health-related quality of life assessed by the 36-Item Short-Form Health Survey (SF-36) (β = 6.31, p = 0.00009).

Conclusions: The rs2228570 polymorphism in the VDR gene is associated with distinct perioperative inflammatory, hematologic, and patient-reported profiles. These findings support the potential clinical utility of VDR genotyping, in combination with routine laboratory tests, to refine perioperative risk stratification and guide personalized rehabilitation in orthopedic patients.

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血清25(OH)D: VDR rs2228570 （FokI）多态性、炎症和骨科患者的生活质量

背景：维生素D受体（VDR）多态性可能影响免疫调节和肌肉骨骼健康，但其围手术期作用尚不清楚。本研究调查了rs2228570 （FokI）变异与骨科患者炎症、血液学和患者报告的预后的关系。方法：采用实时荧光定量PCR对300例骨科患者和200例健康对照进行基因分型。校正年龄和体重指数（BMI）的患者回归模型检验了rs2228570基因型与实验室和临床结果之间的关联。结果：CC基因型（纯合子胞嘧啶）与白细胞计数增高（β = 0.52, p = 0.0435）、淋巴细胞计数增高（β = 0.26, p = 0.00025）、血红蛋白增高（β = 0.57, p = 0.00197）、红细胞压积增高（β = 1.42, p = 0.01102）相关。TT基因型（纯合子胸腺嘧啶）与较高的c反应蛋白（β = 10.90, p = 0.00329）、较低的平均红细胞体积（β = -1.63, p = 0.04909）以及36项简短健康调查（SF-36）评估的较高的健康相关生活质量相关（β = 6.31, p = 0.00009）。结论：VDR基因rs2228570多态性与围手术期不同的炎症、血液学和患者报告的情况有关。这些发现支持了VDR基因分型与常规实验室检测相结合的潜在临床应用，以完善骨科患者围手术期风险分层并指导个性化康复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.