Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.

IF 5 2区 医学 Q1 NUTRITION & DIETETICS
Nutrients Pub Date : 2025-09-18 DOI:10.3390/nu17182991
Alejandro Bruna-Mejías, Rocío Valdivia-Arroyo, Emelyn Sofia Becerra-Rodríguez, Ignacio Clasing-Cárdenas, Yesica Tatiana Castaño-Gallego, Guinevere Granite, Mathias Orellana-Donoso, Gustavo Oyanedel-Amaro, Pablo Nova-Baeza, Gloria Cifuentes-Suazo, Alejandra Suazo-Santibañez, Juan Sanchis-Gimeno, Héctor Gutiérrez Espinoza, Juan José Valenzuela-Fuenzalida
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引用次数: 0

Abstract

Background and Aims: Numerous clinical and observational studies have examined the role of vitamin D in glycemic control and metabolic regulation among diabetic patients, but findings remain inconsistent. This meta-analysis aimed to assess the effects of vitamin D supplementation on glycosylated hemoglobin (HbA1c%), HOMA-IR, HOMA-β, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting plasma glucose, C-reactive protein, and the likelihood of reversion to normoglycemia in prediabetic individuals. Methods: A comprehensive search of multiple databases was performed using keywords including "diabetes mellitus," "type 2 diabetes," "vitamin D supplementation," and "VD supplementation." Twenty studies met the inclusion criteria. Results: Vitamin D supplementation was associated with significant improvements across several parameters, including HOMA-β (SMD = 0.71; 95% CI: 0.63-0.80; p < 0.00001), HDL cholesterol (SMD = 0.07; 95% CI: 0.05-0.09; p < 0.00001), and others (SMD = -0.40; 95% CI: -0.45 to -0.34; p < 0.00001). Conclusions: Vitamin D supplementation appears to provide beneficial effects on glycemic, lipid, and inflammatory markers in patients with diabetes and prediabetes. Specifically, supplementation significantly reduced HbA1c%, HOMA-IR, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting glucose, and C-reactive protein while increasing the rate of normoglycemia among prediabetic individuals. Further research is needed to strengthen the evidence base regarding vitamin D's role in diabetes management.

补充维生素D对不同类型糖尿病患者生化、临床和炎症参数的影响:一项系统综述和荟萃分析
背景和目的:许多临床和观察性研究已经研究了维生素D在糖尿病患者血糖控制和代谢调节中的作用,但结果仍然不一致。本荟萃分析旨在评估补充维生素D对糖尿病前期个体糖化血红蛋白(HbA1c%)、HOMA- ir、HOMA-β、LDL胆固醇、总胆固醇、甘油三酯、空腹胰岛素、空腹血糖、c反应蛋白的影响,以及恢复到正常血糖的可能性。方法:以“糖尿病”、“2型糖尿病”、“维生素D补充”、“VD补充”等关键词对多个数据库进行综合检索。20项研究符合纳入标准。结果:补充维生素D与几个参数的显著改善相关,包括HOMA-β (SMD = 0.71; 95% CI: 0.63-0.80; p < 0.00001),高密度脂蛋白胆固醇(SMD = 0.07; 95% CI: 0.05-0.09; p < 0.00001)和其他(SMD = -0.40; 95% CI: -0.45至-0.34;p < 0.00001)。结论:补充维生素D似乎对糖尿病和前驱糖尿病患者的血糖、脂质和炎症指标有有益的影响。具体来说,补充剂显著降低了HbA1c%、HOMA-IR、LDL胆固醇、总胆固醇、甘油三酯、空腹胰岛素、空腹血糖和c反应蛋白,同时增加了糖尿病前期个体的正常血糖率。需要进一步的研究来加强维生素D在糖尿病管理中的作用的证据基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrients
Nutrients NUTRITION & DIETETICS-
CiteScore
9.20
自引率
15.30%
发文量
4599
审稿时长
16.74 days
期刊介绍: Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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