Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.
Alejandro Bruna-Mejías, Rocío Valdivia-Arroyo, Emelyn Sofia Becerra-Rodríguez, Ignacio Clasing-Cárdenas, Yesica Tatiana Castaño-Gallego, Guinevere Granite, Mathias Orellana-Donoso, Gustavo Oyanedel-Amaro, Pablo Nova-Baeza, Gloria Cifuentes-Suazo, Alejandra Suazo-Santibañez, Juan Sanchis-Gimeno, Héctor Gutiérrez Espinoza, Juan José Valenzuela-Fuenzalida
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Abstract
Background and Aims: Numerous clinical and observational studies have examined the role of vitamin D in glycemic control and metabolic regulation among diabetic patients, but findings remain inconsistent. This meta-analysis aimed to assess the effects of vitamin D supplementation on glycosylated hemoglobin (HbA1c%), HOMA-IR, HOMA-β, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting plasma glucose, C-reactive protein, and the likelihood of reversion to normoglycemia in prediabetic individuals. Methods: A comprehensive search of multiple databases was performed using keywords including "diabetes mellitus," "type 2 diabetes," "vitamin D supplementation," and "VD supplementation." Twenty studies met the inclusion criteria. Results: Vitamin D supplementation was associated with significant improvements across several parameters, including HOMA-β (SMD = 0.71; 95% CI: 0.63-0.80; p < 0.00001), HDL cholesterol (SMD = 0.07; 95% CI: 0.05-0.09; p < 0.00001), and others (SMD = -0.40; 95% CI: -0.45 to -0.34; p < 0.00001). Conclusions: Vitamin D supplementation appears to provide beneficial effects on glycemic, lipid, and inflammatory markers in patients with diabetes and prediabetes. Specifically, supplementation significantly reduced HbA1c%, HOMA-IR, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting glucose, and C-reactive protein while increasing the rate of normoglycemia among prediabetic individuals. Further research is needed to strengthen the evidence base regarding vitamin D's role in diabetes management.
期刊介绍:
Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.