The association between dyslipidemia and intervertebral disc degeneration: a prospective cohort study based on the UK biobank.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-09-26 DOI:10.1186/s12944-025-02687-3

Wangim Choi, Bo Gao, Jianan Chen, Tongzhou Liang, Wenjun Hu, Zaoqiang Zhang, Nianchun Liao, Huihong Shi, Song Liu, Yanbo Chen, Youxi Lin, Zhihuai Deng, Dongsheng Huang, Xianjian Qiu, Peijie Shi, Wenjie Gao

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引用次数: 0

Abstract

Background: Intervertebral disc degeneration (IDD) is a progressive and debilitating condition associated with aging, inflammation, and metabolic disorders. Although dyslipidemia has been implicated in IDD pathogenesis, large-scale prospective evidence remains limited. This study aimed to investigate the observational association between serum lipid traits and IDD risk using data from the UK Biobank.

Methods: A prospective cohort study was conducted among 298,226 participants (aged 37-73 years; 54.2% female, n = 161,770) without IDD at baseline. Serum lipid levels, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A (Apo A) and apolipoprotein B (Apo B), were measured at enrollment. IDD cases were identified via ICD-10 codes. Cox proportional hazards models, adjusted for demographic, lifestyle, and comorbid factors, were used to assess associations between lipid levels and IDD risk. Restricted cubic spline analyses explored potential nonlinear relationships, and subgroup analyses examined effect modifications.

Results: Over a median follow-up of 12 years, 8,745 participants developed IDD. Higher levels of TC (> 5.64 mmol/L) and TG (> 1.51 mmol/L) were significantly associated with increased IDD risk. Compared with the lowest quintile, the highest TC quintile was associated with a 10.2% increased risk (HR = 1.102; 95% CI: 1.029-1.181; P = 0.006), and the highest TG quintile with an 11.3% increased risk (HR = 1.113; 95% CI: 1.036-1.195; P = 0.003), after full adjustment. No significant associations were found for LDL-C, HDL-C, Apo A, or Apo B after multivariable adjustment (all P > 0.05). Subgroup analyses revealed significant interactions between age and TG (P for interaction < 0.05), with younger participants (≤ 60 years) showing a stronger association. Additionally, age modified the effects of HDL-C and Apo A. These findings provide observational evidence that lipid traits may be differentially associated with IDD risk across age groups.

Conclusions: Higher TC and TG levels were associated with increased IDD risk. These findings provide observational evidence for the role of lipid levels in stratifying IDD risk. Routine lipid screening may help identify high-risk individuals and guide early prevention strategies.

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血脂异常与椎间盘退变之间的关系：一项基于英国生物库的前瞻性队列研究。

背景：椎间盘退变（IDD）是一种与衰老、炎症和代谢紊乱相关的进行性和衰弱性疾病。尽管血脂异常与缺乏症的发病机制有关，但大规模的前瞻性证据仍然有限。本研究旨在利用英国生物银行（UK Biobank）的数据，调查血脂特征与IDD风险之间的观察性关联。方法：对基线无IDD的298,226名参与者（年龄37-73岁，54.2%为女性，n = 161,770）进行前瞻性队列研究。入组时测定血清脂质水平，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A （Apo A）和载脂蛋白B （Apo B）。通过ICD-10代码确定IDD病例。Cox比例风险模型经人口统计学、生活方式和合并症因素调整后，用于评估血脂水平与IDD风险之间的关系。限制三次样条分析探讨了潜在的非线性关系，亚群分析检验了效果的变化。结果：在中位随访12年期间，8745名参与者发展为IDD。较高的TC （> 5.64 mmol/L）和TG （> 1.51 mmol/L）水平与IDD风险增加显著相关。完全校正后，与最低五分位数相比，最高TC五分位数与风险增加10.2%相关（HR = 1.102; 95% CI: 1.029-1.181; P = 0.006），最高TG五分位数与风险增加11.3%相关（HR = 1.113; 95% CI: 1.036-1.195; P = 0.003）。多变量校正后，LDL-C、HDL-C、Apo A、Apo B无显著相关性（P < 0.05）。亚组分析显示年龄和TG之间存在显著的相互作用（P为相互作用）。结论：较高的TC和TG水平与IDD风险增加相关。这些发现为脂质水平在IDD风险分层中的作用提供了观察性证据。常规脂质筛查可能有助于识别高危个体并指导早期预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.